Production of sesterterpene ophiobolin by a bifunctional terpene synthase in Escherichia coli
Sign Up to like & getrecommendations! Published in 2019 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-019-10103-x
Abstract: Ophiobolins (ophs) are characteristic 5-8-5 tricyclic sesterterpenes with potential pharmaceutical activities. Ophiobolin synthase is a bifunctional terpene synthase (BTS) that catalyzes both chain elongation and cyclization. In Aspergillus ustus 094102, ophiobolin accumulation was involved with… read more here.
Keywords: production; synthase; bifunctional terpene; terpene ... See more keywords
Chemical control over the conversion between bicyclic and polycyclic terpenes by fungal bifunctional terpene synthases.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc03644d
Abstract: Fungal bifunctional terpene synthases (BFTSs) reportedly associate with a series of new skeletons of di/sesterterpenes. However, the molecular mechanisms underlying the variabilities in the ring system of BFTS-catalyzed products are not well understood. In this… read more here.
Keywords: bifunctional terpene; conversion bicyclic; terpene; bicyclic polycyclic ... See more keywords