Synthesis, structure characterization, and anticancer activity of a novel oxygen-bridged tricyclic Biginelli adduct
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DOI: 10.1016/j.molstruc.2017.02.091
Abstract: Abstract Herein, we report the one-pot cyclization of Biginelli Adduct, ethyl 4-(2-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate ( I) to the oxygen-bridged adduct, ethyl 2-methyl-4-thioxo-3,4,5,6-tetrahydro-2 H -2,6-methanobenzo[ g ] [1,3,5]oxadiazocine-11-carboxylate ( II) in a high yield and purity under mild… read more here.
Keywords: adduct; oxygen bridged; anticancer activity; structure ... See more keywords