Bile Acid Conjugation on Solid Nanoparticles Enhances ASBT‐Mediated Endocytosis and Chylomicron Pathway but Weakens the Transcytosis by Inducing Transport Flow in a Cellular Negative Feedback Loop
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202201414
Abstract: Bile acid‐modified nanoparticles provide a convenient strategy to improve oral bioavailability of poorly permeable drugs by exploiting specific interactions with bile acid transporters. However, the underlying mechanisms are unknown, especially considering the different absorption sites… read more here.
Keywords: acid; transport; negative feedback; conjugation ... See more keywords
Antibiotic‐Induced Gut Microbiota Dysbiosis Modulates Host Transcriptome and m6A Epitranscriptome via Bile Acid Metabolism
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202307981
Abstract: Gut microbiota can influence host gene expression and physiology through metabolites. Besides, the presence or absence of gut microbiome can reprogram host transcriptome and epitranscriptome as represented by N6‐methyladenosine (m6A), the most abundant mammalian mRNA… read more here.
Keywords: m6a; gut microbiota; bile acid; m6a epitranscriptome ... See more keywords
Targeting FDFT1 Reduces Cholesterol and Bile Acid Production and Delays Hepatocellular Carcinoma Progression Through the HNF4A/ALDOB/AKT1 Axis
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202411719
Abstract: Targeting cholesterol metabolism is a novel direction for tumor therapy. Unfortunately, the current use of statins for hepatocellular carcinoma (HCC) is controversial. Herein, farnesyl‐diphosphate farnesyltransferase 1 (FDFT1) is identified as a novel target for treating… read more here.
Keywords: reduces cholesterol; aldob; bile acid; hepatocellular carcinoma ... See more keywords
Bile acid‐based advanced drug delivery systems, bilosomes and micelles as novel carriers for therapeutics
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3732
Abstract: Diabetes mellitus affects almost half a billion patients worldwide and results from either destruction of β‐cells responsible for insulin secretion or increased tissue resistance to insulin stimulation and the reduction of glycemic control. Novel drug… read more here.
Keywords: delivery systems; acid based; drug delivery; drug ... See more keywords
Chemical‐Shift Perturbations Reflect Bile Acid Binding to Norovirus Coat Protein: Recognition Comes in Different Flavors
Sign Up to like & getrecommendations! Published in 2019 at "Chembiochem"
DOI: 10.1002/cbic.201900572
Abstract: Bile acids have been reported as important cofactors promoting human and murine norovirus (NoV) infections in cell culture. The underlying mechanisms are not resolved. Through the use of chemical shift perturbation (CSP) NMR experiments, we… read more here.
Keywords: coat protein; chemical shift; acid binding; acid ... See more keywords
Bile Acid Profile Differs Between Brain Regions in Rodents and Is Disrupted in a Rodent Model of Alzheimer's Disease
Sign Up to like & getrecommendations! Published in 2025 at "Comprehensive Physiology"
DOI: 10.1002/cph4.70034
Abstract: Low but biologically relevant levels of bile acids are found in the brain and are altered in patients with Alzheimer's disease (AD). However, the regulation of brain bile acid levels and what drives brain bile… read more here.
Keywords: bile acid; brain; brain regions; acid profile ... See more keywords
New therapeutic concepts in bile acid transport and signaling for management of cholestasis
Sign Up to like & getrecommendations! Published in 2017 at "Hepatology"
DOI: 10.1002/hep.28991
Abstract: The identification of the key regulators of bile acid (BA) synthesis and transport within the enterohepatic circulation has revealed potential targets for pharmacological therapies of cholestatic liver diseases. Novel drug targets include the bile BA… read more here.
Keywords: transport signaling; transport; new therapeutic; therapeutic concepts ... See more keywords
Chromium exposure altered metabolome and microbiome‐associated with neurotoxicity in zebrafish
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4440
Abstract: In recent years, chromium (Cr) has been found to induce neurotoxicity. However, the underlying mechanism remains unclear. This study aimed to investigate the effects of chromium exposure on the metabolome and microbiome that may contribute… read more here.
Keywords: chromium exposure; metabolome microbiome; exposed groups; bile acid ... See more keywords
Oleanolic acid induces hepatic injury by disrupting hepatocyte tight junction and dysregulation of farnesoid X receptor‐mediated bile acid efflux transporters
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4667
Abstract: Oleanolic acid (OA) is a naturally occurring pentacyclic triterpene compound that has been reported to cause cholestatic liver injury. However, the regulation and pathogenic role of bile acids in OA‐induced development of cholestatic liver injury… read more here.
Keywords: receptor; bile acid; liver injury; injury ... See more keywords
A simple and reliable bile acid assay in human serum by LC‐MS/MS
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24279
Abstract: Bile acids, as important signaling molecules and regulatory factors acting on glucose, lipid, and energy metabolism, are always involved in liver, biliary, and intestinal diseases. Development and validation of a simple liquid chromatography–tandem mass spectrometry… read more here.
Keywords: acid assay; reliable bile; simple reliable; simple ... See more keywords
CEBPB regulates the bile acid receptor FXR to accelerate colon cancer progression by modulating aerobic glycolysis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24703
Abstract: Aerobic glycolysis is a main characteristic of tumors, and inhibited glycolysis impedes the tumor development. Farnesoid X Receptor (FXR) mainly regulates bile acid metabolism. In this research, we mainly investigated whether FXR was involved in… read more here.
Keywords: aerobic glycolysis; receptor fxr; glycolysis; colon cancer ... See more keywords