Bile Acid Conjugation on Solid Nanoparticles Enhances ASBT‐Mediated Endocytosis and Chylomicron Pathway but Weakens the Transcytosis by Inducing Transport Flow in a Cellular Negative Feedback Loop
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202201414
Abstract: Bile acid‐modified nanoparticles provide a convenient strategy to improve oral bioavailability of poorly permeable drugs by exploiting specific interactions with bile acid transporters. However, the underlying mechanisms are unknown, especially considering the different absorption sites… read more here.
Keywords: acid; transport; negative feedback; conjugation ... See more keywords
Bile acid‐based advanced drug delivery systems, bilosomes and micelles as novel carriers for therapeutics
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3732
Abstract: Diabetes mellitus affects almost half a billion patients worldwide and results from either destruction of β‐cells responsible for insulin secretion or increased tissue resistance to insulin stimulation and the reduction of glycemic control. Novel drug… read more here.
Keywords: delivery systems; acid based; drug delivery; drug ... See more keywords
Chemical‐Shift Perturbations Reflect Bile Acid Binding to Norovirus Coat Protein: Recognition Comes in Different Flavors
Sign Up to like & getrecommendations! Published in 2019 at "Chembiochem"
DOI: 10.1002/cbic.201900572
Abstract: Bile acids have been reported as important cofactors promoting human and murine norovirus (NoV) infections in cell culture. The underlying mechanisms are not resolved. Through the use of chemical shift perturbation (CSP) NMR experiments, we… read more here.
Keywords: coat protein; chemical shift; acid binding; acid ... See more keywords
New therapeutic concepts in bile acid transport and signaling for management of cholestasis
Sign Up to like & getrecommendations! Published in 2017 at "Hepatology"
DOI: 10.1002/hep.28991
Abstract: The identification of the key regulators of bile acid (BA) synthesis and transport within the enterohepatic circulation has revealed potential targets for pharmacological therapies of cholestatic liver diseases. Novel drug targets include the bile BA… read more here.
Keywords: transport signaling; transport; new therapeutic; therapeutic concepts ... See more keywords
Chromium exposure altered metabolome and microbiome‐associated with neurotoxicity in zebrafish
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4440
Abstract: In recent years, chromium (Cr) has been found to induce neurotoxicity. However, the underlying mechanism remains unclear. This study aimed to investigate the effects of chromium exposure on the metabolome and microbiome that may contribute… read more here.
Keywords: chromium exposure; metabolome microbiome; exposed groups; bile acid ... See more keywords
A simple and reliable bile acid assay in human serum by LC‐MS/MS
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24279
Abstract: Bile acids, as important signaling molecules and regulatory factors acting on glucose, lipid, and energy metabolism, are always involved in liver, biliary, and intestinal diseases. Development and validation of a simple liquid chromatography–tandem mass spectrometry… read more here.
Keywords: acid assay; reliable bile; simple reliable; simple ... See more keywords
CEBPB regulates the bile acid receptor FXR to accelerate colon cancer progression by modulating aerobic glycolysis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24703
Abstract: Aerobic glycolysis is a main characteristic of tumors, and inhibited glycolysis impedes the tumor development. Farnesoid X Receptor (FXR) mainly regulates bile acid metabolism. In this research, we mainly investigated whether FXR was involved in… read more here.
Keywords: aerobic glycolysis; receptor fxr; glycolysis; colon cancer ... See more keywords
Elevated oxysterol and N‐palmitoyl‐O‐phosphocholineserine levels in congenital disorders of glycosylation
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12595
Abstract: Congenital disorders of glycosylation (CDG) and Niemann‐Pick type C (NPC) disease are inborn errors of metabolism that can both present with infantile‐onset severe liver disease and other multisystemic manifestations. Plasma bile acid and N‐palmitoyl‐O‐phosphocholineserine (PPCS)… read more here.
Keywords: cdg; disease; disorders glycosylation; palmitoyl phosphocholineserine ... See more keywords
Investigation of the Potential of Bile Acid Methyl Esters as Inhibitors of Aldo‐keto Reductase 1C2: Insight from Molecular Docking, Virtual Screening, Experimental Assays and Molecular Dynamics
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Informatics"
DOI: 10.1002/minf.202100256
Abstract: Human aldo‐keto reductase 1C isoforms (AKR1C1‐C4) catalyze reduction of endogenous and exogenous compounds, including therapeutic drugs, and are associated with chemotherapy resistance. AKR1C2 is involved in metastatic processes and is a target for the treatment… read more here.
Keywords: molecular docking; bile acid; acid methyl; methyl esters ... See more keywords
Intrahepatic cholestasis of pregnancy: machine-learning algorithm to predict elevated bile acid based on clinical and laboratory data
Sign Up to like & getrecommendations! Published in 2021 at "Archives of Gynecology and Obstetrics"
DOI: 10.1007/s00404-021-05994-z
Abstract: Applying machine-learning models to clinical and laboratory features of women with intrahepatic cholestasis of pregnancy (ICP) and creating algorithm to identify these patients without bile acid measurements. This retrospective study included 336 pregnant women with… read more here.
Keywords: bile acid; machine learning; clinical laboratory; elevated bile ... See more keywords
Serum bile acid levels assist the prediction of biliary stricture and survival after liver transplantation in children
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Pediatrics"
DOI: 10.1007/s00431-021-04098-9
Abstract: Biliary stricture is an important biliary complication after liver transplant in children. We aimed to investigate the utility of serum bile acid levels for prediction of biliary stricture in children after liver transplant. This study… read more here.
Keywords: serum bile; liver; stricture; biliary stricture ... See more keywords