Formation of functional, extended bile canaliculi, and increased bile acid production in sandwich-cultured human cryopreserved hepatocytes using commercially available culture medium
Sign Up to like & getrecommendations! Published in 2024 at "Archives of Toxicology"
DOI: 10.1007/s00204-024-03757-8
Abstract: Drug-induced cholestasis results in drug discontinuation and market withdrawal, and the prediction of cholestasis risk is critical in the early stages of drug development. Animal tests and membrane vesicle assay are currently being conducted to… read more here.
Keywords: extended bile; bile canaliculi; formation; culture ... See more keywords
Bile canaliculi formation in primary hepatocytes requires α1β1 integrin-dependent adherens junction re-organization.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of cell science"
DOI: 10.1242/jcs.264412
Abstract: ABSTRACT Hepatocytes, the parenchymal cells of the liver, exhibit a unique epithelial polarity phenotype in which their bile canaliculi-forming luminal domains and underlying F-actin-linked cell–cell adhesion belt organize not parallel but perpendicular to their basal… read more here.
Keywords: requires integrin; bile canaliculi; dependent adherens; canaliculi formation ... See more keywords
Activation of S1PR2 on macrophages and the hepatocyte S1PR2/RhoA/ROCK1/MLC2 pathway in vanishing bile duct syndrome
Sign Up to like & getrecommendations! Published in 2025 at "PLOS ONE"
DOI: 10.1371/journal.pone.0317568
Abstract: Immunologic bile duct destruction is a pathogenic condition associated with vanishing bile duct syndrome (VBDS) after liver transplantation and hematopoietic stem-cell transplantation. As the bile acid receptor sphingosine 1-phosphate receptor 2 (S1PR2) plays a critical… read more here.
Keywords: bile canaliculi; s1pr2; rhoa rock1; bile duct ... See more keywords