p16 INK4A drives non-alcoholic fatty liver disease phenotypes in high fat diet fed mice via biliary e2f1/foxo1/igf-1 signaling.
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DOI: 10.1097/hep.0000000000000307
Abstract: BACKGROUNDAND AIM Non-alcoholic fatty liver disease (NAFLD) is characterized by steatosis, hepatic inflammation, and fibrosis which can develop into non-alcoholic steatohepatitis (NASH). NAFLD/NASH patients have increased ductular reaction (DR) and biliary senescence. High fat/high cholesterol… read more here.
Keywords: igf signaling; biliary e2f1; e2f1 foxo1; e2f1 ... See more keywords