Human biliary epithelial cells for regenerative medicine.
Sign Up to like & getrecommendations! Published in 2022 at "Cell stem cell"
DOI: 10.1016/j.stem.2022.02.001
Abstract: In this issue of Cell Stem Cell, Hallett et al. demonstrate the therapeutic potential of human biliary epithelial cells (hBECs) purified from discarded donor livers in a murine model of biliary disease. hBEC transplantation helped to… read more here.
Keywords: human biliary; medicine; biliary epithelial; epithelial cells ... See more keywords
Human biliary epithelial cells from discarded donor livers rescue bile duct structure and function in a mouse model of biliary disease
Sign Up to like & getrecommendations! Published in 2022 at "Cell Stem Cell"
DOI: 10.1016/j.stem.2022.02.006
Abstract: Summary Biliary diseases can cause inflammation, fibrosis, bile duct destruction, and eventually liver failure. There are no curative treatments for biliary disease except for liver transplantation. New therapies are urgently required. We have therefore purified… read more here.
Keywords: bile duct; biliary disease; human biliary; biliary epithelial ... See more keywords
Axin2+ peribiliary glands in the periampullary region generate biliary epithelial stem cells that give rise to ampullary carcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "Gastroenterology"
DOI: 10.1053/j.gastro.2021.01.028
Abstract: BACKGROUND AND AIMS Peribiliary glands (PBGs), clusters of epithelial cells residing in the submucosal compartment of extrahepatic bile ducts, have been suggested as biliary epithelial stem/progenitor cell niche; however, evidence to support this claim is… read more here.
Keywords: epithelial stem; ampullary carcinoma; periampullary region; biliary epithelial ... See more keywords
Recent Advances in Intrahepatic Biliary Epithelial Heterogeneity
Sign Up to like & getrecommendations! Published in 2022 at "Seminars in Liver Disease"
DOI: 10.1055/s-0042-1758833
Abstract: Biliary epithelium (i.e., cholangiocytes) is a heterogeneous population of epithelial cells in the liver, which line small and large bile ducts and have individual responses and functions dependent on size and location in the biliary… read more here.
Keywords: heterogeneity; biliary epithelial; intrahepatic biliary; epithelial heterogeneity ... See more keywords
Anti-fibrotic effect of human amniotic fluid stem cells in biliary epithelial-mesenchymal transition of liver ductal organoid
Sign Up to like & getrecommendations! Published in 2025 at "Stem Cells Translational Medicine"
DOI: 10.1093/stcltm/szaf052
Abstract: Abstract Purpose In biliary atresia (BA), it has been demonstrated that biliary epithelial-mesenchymal transition (EMT) of reactive ductular cells is associated with liver fibrosis. This study aimed to develop an ex vivo biliary EMT model… read more here.
Keywords: biliary emt; stem cells; emt; liver ductal ... See more keywords
CCL5 is induced by TLR 3 signaling in HuCCT1 human biliary epithelial cells: possible involvement in the pathogenesis of biliary atresia.
Sign Up to like & getrecommendations! Published in 2017 at "Biomedical research"
DOI: 10.2220/biomedres.38.269
Abstract: Biliary atresia (BA) is a disease of the newborn that is characterized by progressive, inflammatory and sclerosing cholangiopathy. Innate immune responses to viral components are thought to be involved in the pathogenesis of BA. It… read more here.
Keywords: ccl5; human biliary; pathogenesis; biliary atresia ... See more keywords
Hepatic lipid overload triggers biliary epithelial cell activation via E2Fs
Sign Up to like & getrecommendations! Published in 2023 at "eLife"
DOI: 10.7554/elife.81926
Abstract: During severe or chronic hepatic injury, biliary epithelial cells (BECs) undergo rapid activation into proliferating progenitors, a crucial step required to establish a regenerative process known as ductular reaction (DR). While DR is a hallmark… read more here.
Keywords: cell; biliary epithelial; hepatic lipid; lipid overload ... See more keywords