Association Between Aspirin Use and Biliary Tract Cancer Survival
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DOI: 10.1001/jamaoncol.2019.4328
Abstract: This database study analyzes the association between aspirin use and survival in patients with biliary tract cancer. read more here.
Keywords: aspirin use; association aspirin; tract cancer; biliary tract ... See more keywords
A randomized, double‐blind, phase II study of oral histone deacetylase inhibitor resminostat plus S‐1 versus placebo plus S‐1 in biliary tract cancers previously treated with gemcitabine plus platinum‐based chemotherapy
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Medicine"
DOI: 10.1002/cam4.3813
Abstract: Effective second‐line chemotherapy options are limited in treating advanced biliary tract cancers (BTCs). Resminostat is an oral histone deacetylase inhibitor. Such inhibitors increase sensitivity to fluorouracil, the active form of S‐1. In the phase I… read more here.
Keywords: biliary tract; resminostat; study; histone deacetylase ... See more keywords
Tolerability and efficacy of durvalumab, either as monotherapy or in combination with tremelimumab, in patients from Asia with advanced biliary tract, esophageal, or head‐and‐neck cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.4593
Abstract: Agents targeting the programmed cell death‐1 pathway have demonstrated encouraging activity across multiple solid tumor types. The dose expansion phase of this phase I study evaluated the safety, tolerability, and antitumor activity of durvalumab monotherapy,… read more here.
Keywords: head neck; durvalumab; tolerability; biliary tract ... See more keywords
Statins associate with lower risk of biliary tract cancers: A systematic review and meta‐analysis
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DOI: 10.1002/cam4.4942
Abstract: Biliary tract cancers (BTCs), encompassing cholangiocarcinoma (CCA), gallbladder (GBC), and ampulla of Vater cancers (AVC), are common hepatobiliary cancer after hepatocellular carcinoma with a high mortality rate. As there is no effective chemopreventive agent to… read more here.
Keywords: associate lower; statins associate; tract cancers; biliary tract ... See more keywords
Main causes of death in advanced biliary tract cancer
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DOI: 10.1002/cam4.5794
Abstract: There are no previous reports on the main causes of death in biliary tract cancer (BTC) patients. This study aimed to evaluate the main causes of death and survival rates in patients with BTC. read more here.
Keywords: causes death; biliary tract; main causes; tract cancer ... See more keywords
A multi‐institutional phase 2 trial of regorafenib in refractory advanced biliary tract cancer
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DOI: 10.1002/cncr.32964
Abstract: Regorafenib is an oral multikinase inhibitor targeting angiogenesis, oncogenesis, and cancer proliferation/metastasis. This study evaluated the efficacy of regorafenib in refractory biliary tract cancer (BTC) in a multi‐institutional phase 2 study. read more here.
Keywords: biliary tract; regorafenib refractory; tract cancer; multi institutional ... See more keywords
Is there a role for combined anti–PD‐1/CTLA‐4 checkpoint blockade in the management of advanced biliary tract cancers?
Sign Up to like & getrecommendations! Published in 2023 at "Cancer"
DOI: 10.1002/cncr.34660
Abstract: Sahai et al. recently reported on a randomized phase 2 trial (BilT‐ 01) investigating chemoimmunotherapy (including the anti–PD‐1 antibody nivolumab) versus combined anti–PD‐1/CTLA‐4 checkpoint blockade (using nivolumab and ipilimumab) in patients with advanced biliary tract… read more here.
Keywords: combination; advanced biliary; tract cancers; treatment ... See more keywords
Postdiagnosis Aspirin Use Associated With Decreased Biliary Tract Cancer–Specific Mortality in a Large Nationwide Cohort
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DOI: 10.1002/hep.31879
Abstract: Biliary tract cancer (BTC) is rare and has limited treatment options. We aimed to examine aspirin use on cancer‐specific survival in various BTC subtypes, including gallbladder cancer, ampulla of Vater cancer, and cholangiocarcinoma. read more here.
Keywords: biliary tract; tract cancer; cancer specific; aspirin use ... See more keywords
Letter to the Editor: Proton pump inhibitors and Biliary Tract Cancer Risk: Causality or Reverse Causality?
Sign Up to like & getrecommendations! Published in 2021 at "Hepatology"
DOI: 10.1002/hep.32090
Abstract: We read with enormous interest the study by Kamal et al.1 For the past two decades, dispute on the carcinogenic effects of PPI has remained. In this retrospective study using nationwide registries, long-term use of… read more here.
Keywords: biliary tract; letter editor; tract cancer; causality ... See more keywords
Menopausal hormone therapy and risk of biliary tract cancers: Addressing the ant, not the elephant in the room
Sign Up to like & getrecommendations! Published in 2021 at "Hepatology"
DOI: 10.1002/hep.32254
Abstract: Sex hormones are responsible for multiple physiologic processes by signalling through estrogen (ER) and androgen receptors (AR).(1) ERs and ARs are expressed in liver and biliary tract cells in normal and diseased states in both… read more here.
Keywords: menopausal hormone; biliary tract; hormone therapy; tract ... See more keywords
Transcriptional repression and apoptosis influence the effect of APOBEC3A/3B functional polymorphisms on biliary tract cancer risk
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.33930
Abstract: APOBEC3‐related somatic mutations are predominant in biliary tract cancers (BTCs). We aimed to elucidate the roles of APOBEC3A/3B functional polymorphisms and their influencing factors on the development of cholangiocarcinoma (CCA) and gallbladder cancer (GBC). Polymorphisms… read more here.
Keywords: promoter; apoptosis; risk; activity ... See more keywords