Evaluation of region selective bilirubin-induced brain damage as a basis for a pharmacological treatment
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep41032
Abstract: The neurologic manifestations of neonatal hyperbilirubinemia in the central nervous system (CNS) exhibit high variations in the severity and appearance of motor, auditory and cognitive symptoms, which is suggestive of a still unexplained selective topography… read more here.
Keywords: treatment; evaluation region; bilirubin; damage ... See more keywords
Inflammatory signature of cerebellar neurodegeneration during neonatal hyperbilirubinemia in Ugt1-/- mouse model
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-017-0838-1
Abstract: BackgroundSevere hyperbilirubinemia is toxic during central nervous system development. Prolonged and uncontrolled high levels of unconjugated bilirubin lead to bilirubin-induced neurological damage and eventually death by kernicterus. Bilirubin neurotoxicity is characterized by a wide array… read more here.
Keywords: neonatal hyperbilirubinemia; hyperbilirubinemia; bilirubin; neurodegeneration ... See more keywords
Bilirubin Induced Encephalopathy, a Review Article
Sign Up to like & getrecommendations! Published in 2020 at "Iranian journal of child neurology"
DOI: 10.22037/ijcn.v14i1.27890
Abstract: Hyperbilirubinemia is one of the most common neonatal disorders. Delayed diagnosis and treatment of the pathologic and progressive indirect hyperbilirubinemia lead to neurological deficits, defined as bilirubin induced encephalopathy . The incidence of this disorder… read more here.
Keywords: bilirubin induced; review article; hyperbilirubinemia; encephalopathy review ... See more keywords