Longitudinal Magnetic Resonance Imaging with ROS‐Responsive Bilirubin Nanoparticles Enables Monitoring of Nonalcoholic Steatohepatitis Progression to Cirrhosis
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DOI: 10.1002/adma.202305830
Abstract: Despite the vital importance of monitoring the progression of nonalcoholic fatty liver disease (NAFLD) and its progressive form, nonalcoholic steatohepatitis (NASH), an efficient imaging modality that is readily available at hospitals is currently lacking. Here,… read more here.
Keywords: progression; resonance imaging; bilirubin nanoparticles; magnetic resonance ... See more keywords
Bilirubin Nanoparticle Treatment in Obese Mice Inhibits Hepatic Ceramide Production and Remodels Liver Fat Content
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DOI: 10.3390/metabo13020215
Abstract: Studies have indicated that increasing plasma bilirubin levels might be useful for preventing and treating hepatic lipid accumulation that occurs with metabolic diseases such as obesity and diabetes. We have previously demonstrated that mice with… read more here.
Keywords: fat content; bilirubin nanoparticles; bilirubin; ceramide production ... See more keywords
Thermoresponsive gel containing bilirubin nanoparticles exerts anti-inflammatory effects by inhibiting neutrophil infiltration and augmenting interleukin-10 levels in carrageenan-induced rat paw edema
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DOI: 10.4103/ijp.ijp_525_23
Abstract: BACKGROUND: Topical corticosteroids treat cutaneous inflammation but have side effects. In earlier studies, bilirubin exhibited anti-inflammatory effect, but its hydrophobicity and poor absorption limit its potential. AIM: Synthesis of bilirubin nanoparticles (BNP) and bilirubin nanoparticles… read more here.
Keywords: neutrophil infiltration; gel; paw edema; bilirubin nanoparticles ... See more keywords