Z-FL-COCHO, a cathepsin S inhibitor, enhances oxaliplatin-induced apoptosis through upregulation of Bim expression.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.03.068
Abstract: Inhibition of cathespsin S not only inhibits invasion and angiogenesis, but also induces apoptosis and autophagy in cancer cells. In present study, we revealed that pharmacological inhibitor [Z-FL-COCHO (ZFL)] of cathepsin S up-regulates pro-apoptotic protein… read more here.
Keywords: enhances oxaliplatin; inhibitor; bim expression; apoptosis ... See more keywords
Bim Expression Modulates Branching Morphogenesis of the Epithelium and Endothelium
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DOI: 10.3390/biom12091295
Abstract: Branching morphogenesis is a key developmental process during organogenesis, such that its disruption frequently leads to long-term consequences. The kidney and eye share many etiologies, perhaps, due to similar use of developmental branching morphogenesis and… read more here.
Keywords: branching morphogenesis; ureteric bud; bim expression;
Bim Expression Promotes the Clearance of Mononuclear Phagocytes during Choroidal Neovascularization, Mitigating Scar Formation in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Life"
DOI: 10.3390/life12020208
Abstract: Inflammation is increasingly recognized as an important modulator in the pathogenesis of neovascular age-related macular degeneration (nAMD). Although significant progress has been made in delineating the pathways that contribute to the recruitment of inflammatory cells… read more here.
Keywords: bim expression; scar formation; expression; mice ... See more keywords