Dynamic Thermodynamic Resolution of Racemic 1,1'-Binaphthyl-2,2'-diol (BINOL).
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DOI: 10.1021/acs.orglett.4c00520
Abstract: A dynamic thermodynamic resolution method for converting (R/S)-BINOL (1,1'-binaphthyl-2,2'-diol) into (R)-BINOL in 100% theoretical yield is reported. This technique involves mixing (R/S)-BINOL with N-benzyl cinchonidinium bromide (1 equiv) and a [Cu2(tmeda)2(μ-OH)2]Br2 (2.5 mol %) redox… read more here.
Keywords: thermodynamic resolution; diol binol; binaphthyl diol; dynamic thermodynamic ... See more keywords