Point estimation and p-values in phase II adaptive two-stage designs with a binary endpoint.
Sign Up to like & getrecommendations! Published in 2017 at "Statistics in medicine"
DOI: 10.1002/sim.7200
Abstract: Clinical trials in phase II of drug development are frequently conducted as single-arm two-stage studies with a binary endpoint. Recently, adaptive designs have been proposed for this setting that enable a midcourse modification of the… read more here.
Keywords: estimation; two stage; binary endpoint; point estimation ... See more keywords
A randomized Bayesian optimal phase II design with binary endpoint
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biopharmaceutical Statistics"
DOI: 10.1080/10543406.2022.2094938
Abstract: ABSTRACT In this paper, we propose a randomized Bayesian optimal phase II (RBOP2) design with a binary endpoint (e.g., response rate). A beta-binomial distribution is used to model the binary endpoint for a two-arm phase… read more here.
Keywords: bayesian optimal; randomized bayesian; binary endpoint; design ... See more keywords