Mediation analysis for common binary outcomes.
Sign Up to like & getrecommendations! Published in 2019 at "Statistics in medicine"
DOI: 10.1002/sim.7945
Abstract: Mediation analysis provides an attractive causal inference framework to decompose the total effect of an exposure on an outcome into natural direct effects and natural indirect effects acting through a mediator. For binary outcomes, mediation… read more here.
Keywords: mediation analysis; natural direct; binary outcomes; mediation ... See more keywords
Clinical prediction models to predict the risk of multiple binary outcomes: Methodological issues
Sign Up to like & getrecommendations! Published in 2021 at "Statistics in Medicine"
DOI: 10.1002/sim.8874
Abstract: We read with interest the paper by Martin et al published in Statistics in Medicine.1 The aim of study was to compare four models including: probabilistic classifier chain, multinomial logistic regression, multivariate logistic regression, and… read more here.
Keywords: risk; multiple binary; binary outcomes; prediction models ... See more keywords
Bayesian set of best dynamic treatment regimes: Construction and sample size calculation for SMARTs with binary outcomes
Sign Up to like & getrecommendations! Published in 2022 at "Statistics in Medicine"
DOI: 10.1002/sim.9323
Abstract: Sequential, multiple assignment, randomized trials (SMARTs) compare sequences of treatment decision rules called dynamic treatment regimes (DTRs). In particular, the Adaptive Treatment for Alcohol and Cocaine Dependence (ENGAGE) SMART aimed to determine the best DTRs… read more here.
Keywords: set best; treatment regimes; sample size; dynamic treatment ... See more keywords
A maximum likelihood approach to power calculations for stepped wedge designs of binary outcomes.
Sign Up to like & getrecommendations! Published in 2018 at "Biostatistics"
DOI: 10.1093/biostatistics/kxy031
Abstract: In stepped wedge designs (SWD), clusters are randomized to the time period during which new patients will receive the intervention under study in a sequential rollout over time. By the study's end, patients at all… read more here.
Keywords: binary outcomes; power; approach; stepped wedge ... See more keywords
Modified Brier score for evaluating prediction accuracy for binary outcomes
Sign Up to like & getrecommendations! Published in 2022 at "Statistical Methods in Medical Research"
DOI: 10.1177/09622802221122391
Abstract: The Brier score has been a popular measure of prediction accuracy for binary outcomes. However, it is not straightforward to interpret the Brier score for a prediction model since its value depends on the outcome… read more here.
Keywords: brier score; prediction; binary outcomes; prediction accuracy ... See more keywords
Refined moderation analysis with binary outcomes in precision medicine research
Sign Up to like & getrecommendations! Published in 2023 at "Statistical Methods in Medical Research"
DOI: 10.1177/09622802231151206
Abstract: Moderation analysis for evaluating differential treatment effects serves as the bedrock of precision medicine, which is of growing interest in many fields. In the analysis of data with binary outcomes, we observe an interesting symmetry… read more here.
Keywords: moderation analysis; precision medicine; analysis; binary outcomes ... See more keywords
Assessing and visualizing fragility of clinical results with binary outcomes in R using the fragility package
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0268754
Abstract: With the growing concerns about research reproducibility and replicability, the assessment of scientific results’ fragility (or robustness) has been of increasing interest. The fragility index was proposed to quantify the robustness of statistical significance of… read more here.
Keywords: assessing visualizing; visualizing fragility; fragility package; fragility ... See more keywords
Corrigendum: Relative Measures of Association for Binary Outcomes: Challenges and Recommendations for the Global Health Researcher
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Global Health"
DOI: 10.5334/aogh.2998
Abstract: This article details a correction to the article: Gallis, J. A. and Turner, E. L., 2019. Relative Measures of Association for Binary Outcomes: Challenges and Recommendations for the Global Health Researcher. Annals of Global Health,… read more here.
Keywords: health; global health; relative measures; measures association ... See more keywords