Community-acquired fulminant colitis caused by binary toxin-producing Clostridium difficile in Japan
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Journal of Gastroenterology"
DOI: 10.1007/s12328-019-00949-z
Abstract: We report a case of community-acquired fulminant colitis caused by Clostridium difficile in Japan. A 46-year-old woman was diagnosed with severe infectious enterocolitis and was admitted at another hospital. The stool culture was positive for… read more here.
Keywords: binary toxin; acquired fulminant; difficile; community acquired ... See more keywords
Development of an ADP-ribosylation assay for residual toxicity in C. difficile binary toxin CDTa using automated capillary western blot.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2020.113125
Abstract: CDTa, an actin ADP-ribosylation transferase, is a binary toxin produced by the bacterium Clostridium difficile which is commonly associated with the hypervirulent strain present in Clostridium difficile infections. The mutated form of CDTa, 4mCDTa, is… read more here.
Keywords: binary toxin; difficile; adp ribosylation; residual toxicity ... See more keywords
Serine clamp of Clostridium perfringens binary toxin BECb (CPILEb)-pore confers cytotoxicity and enterotoxicity
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DOI: 10.1038/s42003-025-08519-5
Abstract: BEC (CPILE) is a virulence factor of the pathogen, Clostridium perfringens, which has caused foodborne outbreaks in Japan. BEC is a binary toxin that comprises the enzymatic A-component (BECa) and the B-component (BECb); the latter… read more here.
Keywords: becb; binary toxin; clostridium perfringens; serine ... See more keywords
Influence of Binary Toxin Gene Detection and Decreased Susceptibility to Antibiotics among Clostridioides difficile Strains on Disease Severity: a Single-Center Study
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DOI: 10.1128/aac.00489-22
Abstract: Clostridioides difficile infection (CDI) is the fifth leading cause of death from nonmalignant gastrointestinal disease in the United States. The contribution of resistance to C. difficile-active antibiotics to the outcomes of CDI is unclear. ABSTRACT… read more here.
Keywords: clostridioides difficile; susceptibility; gene; binary toxin ... See more keywords
Prevalence of binary toxin positive Clostridium difficile in diarrhoeal humans in the absence of epidemic ribotype 027
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0187658
Abstract: Virulence of Clostridium difficile is primarily attributed to the large clostridial toxins A and B while the role of binary toxin (CDT) remains unclear. The prevalence of human strains of C. difficile possessing only CDT… read more here.
Keywords: clostridium difficile; binary toxin; difficile; cdt ... See more keywords
Sentinel surveillance and epidemiology of Clostridioides difficile in Denmark, 2016 to 2019
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DOI: 10.2807/1560-7917.es.2022.27.49.2200244
Abstract: Background Since 2008, Danish national surveillance of Clostridioides difficile has focused on binary toxin-positive strains in order to monitor epidemic types such as PCR ribotype (RT) 027 and 078. Additional surveillance is needed to provide… read more here.
Keywords: surveillance; binary toxin; sentinel surveillance; clostridioides difficile ... See more keywords