Identification of claudin-4 binder that attenuates tight junction barrier function by TR-FRET-based screening assay
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DOI: 10.1038/s41598-017-15108-y
Abstract: Claudins are key functional and structural components of tight junctions (TJs) in epithelial cell sheets. The C-terminal fragment of Clostridium perfringens enterotoxin (C-CPE) binds to claudin-4 and reversibly modulates intestinal TJ seals, thereby enhancing paracellular… read more here.
Keywords: binder attenuates; claudin; claudin binder; identification claudin ... See more keywords