Targeting Oligosaccharides and Glycoconjugates Using Superselective Binding Scaffolds
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202002298
Abstract: Abstract Recognition of oligosaccharides is associated with very limited specificity due to their strong solvation in water and the high degree of subtle structural variations between them. Here, oligosaccharide recognition sites are created on material… read more here.
Keywords: binding scaffolds; oligosaccharides glycoconjugates; superselective binding; binding ... See more keywords
Tri- and diorganotin(IV) derivatives of non-steroidal anti-inflammatory drug sulindac: Characterization, electronic structures (DFT), DNA binding and plasmid cleavage studies
Sign Up to like & getrecommendations! Published in 2017 at "Applied Organometallic Chemistry"
DOI: 10.1002/aoc.3661
Abstract: Tri- and diorganotin(IV) derivatives of non-steroidal anti-inflammatory drug sulindac (Sul), coordinated with carboxylate oxygen, namely C23H25FO3SSn (1), C38H31FO3SSn (2), C32H43FO3SSn (3), C52H42F2O6S2Sn (4), C44H44S2Cl2O6F2Sn2 (5), C48H50F2O6S2Sn (6) and C56H66F2O6S2Sn (7), have been synthesized and characterized… read more here.
Keywords: 104 104; dna; drug; binding ... See more keywords
Binding and Enhanced Binding between Key Immunity Proteins TRAF6 and TIFA
Sign Up to like & getrecommendations! Published in 2019 at "ChemBioChem"
DOI: 10.1002/cbic.201800436
Abstract: Human tumor necrosis factor receptor associated factor (TRAF)‐interacting protein, with a forkhead‐associated domain (TIFA), is a key regulator of NF‐κB activation. It also plays a key role in the activation of innate immunity in response… read more here.
Keywords: immunity; enhanced binding; binding; tifa ... See more keywords
Temperature-Controlled Adhesion to Carbohydrate Functionalized Microgel Films: An E. coli and Lectin Binding Study.
Sign Up to like & getrecommendations! Published in 2021 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202000386
Abstract: The preparation of thermoresponsive mannose functionalized monolayers of poly(N-isopropylacrylamide) microgels and the analysis of the specific binding of concanavalin A (ConA) and E. coli above and below the lower critical solution temperature (LCST) are shown.… read more here.
Keywords: temperature controlled; temperature; microgel; lcst ... See more keywords
Detection of electrostatic molecular binding using the water proton signal
Sign Up to like & getrecommendations! Published in 2022 at "Magnetic Resonance in Medicine"
DOI: 10.1002/mrm.29230
Abstract: Saturation transfer MRI has previously been used to probe molecular binding interactions with signal enhancement via the water signal. Here, we detail the relayed nuclear overhauser effect (rNOE) based mechanisms of this signal enhancement, develop… read more here.
Keywords: binding; detection electrostatic; electrostatic molecular; water ... See more keywords
Allosteric discrimination at the NADH/ADP regulatory site of glutamate dehydrogenase
Sign Up to like & getrecommendations! Published in 2019 at "Protein Science"
DOI: 10.1002/pro.3748
Abstract: Glutamate dehydrogenase (GDH) is a target for treating insulin‐related disorders, such as hyperinsulinism hyperammonemia syndrome. Modeling native ligand binding has shown promise in designing GDH inhibitors and activators. Our computational investigation of the nicotinamide adenine… read more here.
Keywords: binding; nadh adp; site; glutamate dehydrogenase ... See more keywords
N‐terminal β‐strand in YAP is critical for stronger binding to scalloped relative to TEAD transcription factor
Sign Up to like & getrecommendations! Published in 2023 at "Protein Science"
DOI: 10.1002/pro.4545
Abstract: The yes‐associated protein (YAP) regulates the transcriptional activity of the TEAD transcription factors that are key in the control of organ morphogenesis. YAP interacts with TEAD via three secondary structure elements: a β‐strand, an α‐helix,… read more here.
Keywords: binding; strand; affinity; tead transcription ... See more keywords
Functional differentiation of two general-odorant binding proteins in Hyphantria cunea (Drury) (Lepidoptera: Erebidae).
Sign Up to like & getrecommendations! Published in 2023 at "Pest management science"
DOI: 10.1002/ps.7515
Abstract: BACKGROUND General odor-binding proteins (GOBPs) play critical roles in insect olfactory recognition of sex pheromones and plant volatiles. Therefore, the identification of GOBPs in Hyphantria cunea (Drury) based on their characterization to pheromone components and… read more here.
Keywords: binding; plant volatiles; cunea drury; binding proteins ... See more keywords
Single-Stranded DNA-Binding Proteins in the Archaea.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1290-3_2
Abstract: Single-stranded (ss) DNA-binding proteins are found in all three domains of life where they play vital roles in nearly all aspects of DNA metabolism by binding to and stabilizing exposed ssDNA and acting as platforms… read more here.
Keywords: single stranded; ssdna binding; binding; stranded dna ... See more keywords
Behaviour of intrinsically disordered proteins in protein–protein complexes with an emphasis on fuzziness
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-017-2560-7
Abstract: Intrinsically disordered proteins (IDPs) do not, by themselves, fold into a compact globular structure. They are extremely dynamic and flexible, and are typically involved in signalling and transduction of information through binding to other macromolecules.… read more here.
Keywords: proteins protein; protein protein; binding; behaviour intrinsically ... See more keywords
Histo-blood group antigens in Crassostrea gigas and binding profiles with GII.4 Norovirus
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Oceanology and Limnology"
DOI: 10.1007/s00343-018-7024-x
Abstract: Noroviruses (NoVs) are the main cause of viral gastroenteritis outbreaks worldwide, and oysters are the most common carriers of NoV contamination and transmission. NoVs bind specifically to oyster tissues through histo-blood group antigens (HBGAs), and… read more here.
Keywords: hbgas; histo blood; bound type; binding ... See more keywords