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   Articles with "binding activity" as a keyword



Mitotic phosphorylation of CCCTC‐binding factor (CTCF) reduces its DNA binding activity

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recommendations! Published in 2017 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.12189

Abstract: During mitosis, higher order chromatin structures are disrupted and chromosomes are condensed to achieve accurate chromosome segregation. CCCTC‐binding factor (CTCF) is a highly conserved and ubiquitously expressed C2H2‐type zinc finger protein which is considered to… read more here.

Keywords: mitosis; ctcf; dna binding; binding activity ... See more keywords

DNA Binding Activity of Functionalized Schiff Base Metal Complexes

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recommendations! Published in 2025 at "European Journal of Inorganic Chemistry"

DOI: 10.1002/ejic.202400705

Abstract: Based on our recent research experience, this review highlights the DNA binding of salen, salphen and salnaphen metal complexes, with a focus on G‐quadruplex (G4) DNA, which is crucial in peculiar genomic regions and in… read more here.

Keywords: binding activity; functionalized schiff; metal; activity functionalized ... See more keywords

A NusG Specialized Paralog That Exhibits Specific, High-Affinity RNA-Binding Activity.

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recommendations! Published in 2021 at "Journal of molecular biology"

DOI: 10.1016/j.jmb.2021.167100

Abstract: Bacterial NusG associates with RNA polymerase (RNAP) through its N-terminal domain, while the C-terminal domain (CTD) forms dynamic interactions with Rho, S10, NusB and NusA to affect transcription elongation. While virtually all bacteria encode for… read more here.

Keywords: specialized paralog; affinity; rna binding; nusg specialized ... See more keywords
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CTP regulates membrane-binding activity of the nucleoid occlusion protein Noc

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recommendations! Published in 2021 at "Molecular Cell"

DOI: 10.1016/j.molcel.2021.06.025

Abstract: Summary ATP- and GTP-dependent molecular switches are extensively used to control functions of proteins in a wide range of biological processes. However, CTP switches are rarely reported. Here, we report that a nucleoid occlusion protein… read more here.

Keywords: membrane binding; ctp; nucleoid occlusion; binding activity ... See more keywords

Maturational Changes of Gamma-Aminobutyric Acid A Receptors Measured With Benzodiazepine Binding of Iodine 123 Iomazenil Single-Photon Emission Computed Tomography.

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recommendations! Published in 2018 at "Pediatric neurology"

DOI: 10.1016/j.pediatrneurol.2018.02.008

Abstract: BACKGROUND Iodine 123 (I-123) iomazenil is a specific ligand of the central benzodiazepine receptor, which is a part of the postsynaptic gamma-aminobutyric acid A receptor complex. We performed statistical image processing of I-123 iomazenil single-photon… read more here.

Keywords: benzodiazepine receptor; 123 iomazenil; receptor; binding activity ... See more keywords
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Benzofuran and coumarin derivatives from the root of Angelica dahurica and their PPAR-γ ligand-binding activity.

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recommendations! Published in 2020 at "Phytochemistry"

DOI: 10.1016/j.phytochem.2020.112301

Abstract: A phytochemical investigation of the root of Angelica dahurica led to the isolation of benzofuran and coumarin derivatives. This is the first report of the isolation and identification of three furanocoumarin sulfates from A. dahurica… read more here.

Keywords: ligand binding; binding activity; ppar ligand;

Fine-Tuning of ATF4 DNA Binding Activity by a Secondary Basic Motif Unique to the ATF-X Subfamily of bZip Transcription Factors

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recommendations! Published in 2025 at "Biochemistry"

DOI: 10.1021/acs.biochem.4c00640

Abstract: The fine-tuning of transcription factor DNA-binding activity is often governed by transient intramolecular interactions between the transactivation domain and the DNA-binding domain. An example of such interaction is found in the transcription factor ATF4, a… read more here.

Keywords: binding activity; secondary basic; atf4 dna; dna binding ... See more keywords

Site-Specific Acetylation of the Transcription Factor Protein Max Modulates Its DNA Binding Activity

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recommendations! Published in 2024 at "ACS Central Science"

DOI: 10.1021/acscentsci.4c00686

Abstract: Chemical protein synthesis provides a powerful means to prepare novel modified proteins with precision down to the atomic level, enabling an unprecedented opportunity to understand fundamental biological processes. Of particular interest is the process of… read more here.

Keywords: binding activity; max; protein; acetylation ... See more keywords
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Structural insights into the π-π-π stacking mechanism and DNA-binding activity of the YEATS domain

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recommendations! Published in 2018 at "Nature Communications"

DOI: 10.1038/s41467-018-07072-6

Abstract: The YEATS domain has been identified as a reader of histone acylation and more recently emerged as a promising anti-cancer therapeutic target. Here, we detail the structural mechanisms for π-π-π stacking involving the YEATS domains… read more here.

Keywords: yeats domain; structural insights; af9 yeats; dna binding ... See more keywords

In vitro DNA binding activity and molecular docking reveals pierisin-5 as an anti-proliferative agent against gastric cancer

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recommendations! Published in 2019 at "Journal of Biomolecular Structure and Dynamics"

DOI: 10.1080/07391102.2019.1659856

Abstract: Abstract Pierisin-5 is a DNA dependent ADP ribosyltransferase (ADRT) protein from the larvae of Indian cabbage white butterfly, Pieris canidia. Interestingly, Pierisin-5 ADP-ribosylates the DNA as a substrate, but not the protein and subsequently persuades… read more here.

Keywords: protein; dna; pierisin; dna binding ... See more keywords

Curcumin analog, GO-Y078, induces HO-1 transactivation-mediated apoptotic cell death of oral cancer cells by triggering MAPK pathways and AP-1 DNA-binding activity

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recommendations! Published in 2022 at "Expert Opinion on Therapeutic Targets"

DOI: 10.1080/14728222.2022.2061349

Abstract: ABSTRACT Background GO-Y078, a new synthetic analogue of curcumin (CUR), has higher oral bioavailability and anticancer activity than CUR, but the oncostatic effect of GO-Y078 on oral squamous cell carcinoma (OSCC) is largely unknown. Research… read more here.

Keywords: cell; binding activity; dna binding; y078 ... See more keywords