Mitotic phosphorylation of CCCTC‐binding factor (CTCF) reduces its DNA binding activity
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12189
Abstract: During mitosis, higher order chromatin structures are disrupted and chromosomes are condensed to achieve accurate chromosome segregation. CCCTC‐binding factor (CTCF) is a highly conserved and ubiquitously expressed C2H2‐type zinc finger protein which is considered to… read more here.
Keywords: mitosis; ctcf; dna binding; binding activity ... See more keywords
A NusG Specialized Paralog That Exhibits Specific, High-Affinity RNA-Binding Activity.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2021.167100
Abstract: Bacterial NusG associates with RNA polymerase (RNAP) through its N-terminal domain, while the C-terminal domain (CTD) forms dynamic interactions with Rho, S10, NusB and NusA to affect transcription elongation. While virtually all bacteria encode for… read more here.
Keywords: specialized paralog; affinity; rna binding; nusg specialized ... See more keywords
CTP regulates membrane-binding activity of the nucleoid occlusion protein Noc
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Cell"
DOI: 10.1016/j.molcel.2021.06.025
Abstract: Summary ATP- and GTP-dependent molecular switches are extensively used to control functions of proteins in a wide range of biological processes. However, CTP switches are rarely reported. Here, we report that a nucleoid occlusion protein… read more here.
Keywords: membrane binding; ctp; nucleoid occlusion; binding activity ... See more keywords
Maturational Changes of Gamma-Aminobutyric Acid A Receptors Measured With Benzodiazepine Binding of Iodine 123 Iomazenil Single-Photon Emission Computed Tomography.
Sign Up to like & getrecommendations! Published in 2018 at "Pediatric neurology"
DOI: 10.1016/j.pediatrneurol.2018.02.008
Abstract: BACKGROUND Iodine 123 (I-123) iomazenil is a specific ligand of the central benzodiazepine receptor, which is a part of the postsynaptic gamma-aminobutyric acid A receptor complex. We performed statistical image processing of I-123 iomazenil single-photon… read more here.
Keywords: benzodiazepine receptor; 123 iomazenil; receptor; binding activity ... See more keywords
Benzofuran and coumarin derivatives from the root of Angelica dahurica and their PPAR-γ ligand-binding activity.
Sign Up to like & getrecommendations! Published in 2020 at "Phytochemistry"
DOI: 10.1016/j.phytochem.2020.112301
Abstract: A phytochemical investigation of the root of Angelica dahurica led to the isolation of benzofuran and coumarin derivatives. This is the first report of the isolation and identification of three furanocoumarin sulfates from A. dahurica… read more here.
Keywords: ligand binding; binding activity; ppar ligand;
Structural insights into the π-π-π stacking mechanism and DNA-binding activity of the YEATS domain
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-07072-6
Abstract: The YEATS domain has been identified as a reader of histone acylation and more recently emerged as a promising anti-cancer therapeutic target. Here, we detail the structural mechanisms for π-π-π stacking involving the YEATS domains… read more here.
Keywords: yeats domain; structural insights; af9 yeats; dna binding ... See more keywords
In vitro DNA binding activity and molecular docking reveals pierisin-5 as an anti-proliferative agent against gastric cancer
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2019.1659856
Abstract: Abstract Pierisin-5 is a DNA dependent ADP ribosyltransferase (ADRT) protein from the larvae of Indian cabbage white butterfly, Pieris canidia. Interestingly, Pierisin-5 ADP-ribosylates the DNA as a substrate, but not the protein and subsequently persuades… read more here.
Keywords: protein; dna; pierisin; dna binding ... See more keywords
Curcumin analog, GO-Y078, induces HO-1 transactivation-mediated apoptotic cell death of oral cancer cells by triggering MAPK pathways and AP-1 DNA-binding activity
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2022.2061349
Abstract: ABSTRACT Background GO-Y078, a new synthetic analogue of curcumin (CUR), has higher oral bioavailability and anticancer activity than CUR, but the oncostatic effect of GO-Y078 on oral squamous cell carcinoma (OSCC) is largely unknown. Research… read more here.
Keywords: cell; binding activity; dna binding; y078 ... See more keywords
The serotype a-EmaA adhesin of Aggregatibacter actinomycetemcomitans does not require O-PS synthesis for collagen binding activity
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology"
DOI: 10.1099/mic.0.001191
Abstract: Aggregatibacter actinomycetemcomitans , a causative agent of periodontitis and non-oral diseases, synthesizes a trimeric extracellular matrix protein adhesin A (EmaA) that mediates collagen binding and biofilm formation. EmaA is found as two molecular forms, which… read more here.
Keywords: binding activity; emaa; collagen binding;
An autoinhibitory mechanism controls RNA‐binding activity of the nitrate‐sensing protein NasR
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Microbiology"
DOI: 10.1111/mmi.14517
Abstract: Abstract The ANTAR domain harnesses RNA‐binding activity to promote transcription attenuation. Although several ANTAR proteins have been analyzed by high‐resolution structural analyses, the residues involved in RNA‐recognition and transcription attenuation have not been identified. Nor… read more here.
Keywords: binding activity; autoinhibitory mechanism; rna binding;
TbRAP1 has an unusual duplex DNA binding activity required for its telomere localization and VSG silencing
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.abc4065
Abstract: The electrostatics-based dsDNA binding activity in TbRAP1 NLS can be diminished by phosphorylation of NLS-adjacent S residues. Localization of Repressor Activator Protein 1 (RAP1) to the telomere is essential for its telomeric functions. RAP1 homologs… read more here.
Keywords: vsg; dna binding; binding activity; localization ... See more keywords