Effects of Single Nucleotide Polymorphisms on the Binding of Afatinib to EGFR: A Potential Patient Stratification Factor Revealed by Modeling Studies
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DOI: 10.1021/acs.jcim.8b00491
Abstract: The anticancer drug afatinib has been found to be more effective at inhibiting the oncogenic EGFR mutant exon 19 deletion (19del) over the oncogenic EGFR mutant L858R. The underlying mechanism has been hypothesized to result… read more here.
Keywords: nucleotide polymorphisms; single nucleotide; binding afatinib; effects single ... See more keywords