Fc‐Binding Antibody‐Recruiting Molecules Targeting Prostate‐Specific Membrane Antigen: Defucosylation of Antibody for Efficacy Improvement **
Sign Up to like & getrecommendations! Published in 2020 at "ChemBioChem"
DOI: 10.1002/cbic.202000577
Abstract: Synthetic small molecules that redirect endogenous antibodies to target cells are promising drug candidates because they overcome the potential shortcomings of therapeutic antibodies, such as immunogenicity and the need for intravenous delivery. Previously, we reported… read more here.
Keywords: prostate; recruiting molecules; antibody; antibody recruiting ... See more keywords
Fc-binding antibody-recruiting molecules exploit endogenous antibodies for anti-tumor immune responses†
Sign Up to like & getrecommendations! Published in 2020 at "Chemical Science"
DOI: 10.1039/d0sc00017e
Abstract: Redirecting endogenous antibodies in the bloodstream to tumor cells using synthetic molecules is a promising approach to trigger anti-tumor immune responses. However, current molecular designs only enable the use of a small fraction of endogenous… read more here.
Keywords: binding antibody; immune responses; endogenous antibodies; anti tumor ... See more keywords
SARS-CoV-2 Spike-Binding Antibody Longevity and Protection from Reinfection with Antigenically Similar SARS-CoV-2 Variants
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DOI: 10.1128/mbio.01784-22
Abstract: SARS-CoV-2 is the cause of one of the largest noninfluenza pandemics of this century. This exceptional public health crisis highlights the urgent need for better understanding of the correlates of protection from infection and severe… read more here.
Keywords: protection; sars cov; spike binding; binding antibody ... See more keywords
Quantification of Severe Acute Respiratory Syndrome Coronavirus 2 Binding Antibody Levels To Assess Infection and Vaccine-Induced Immunity Using WHO Standards
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DOI: 10.1128/spectrum.03709-22
Abstract: Accurate quantification of SARS-CoV-2-specific antibodies can be achieved using a universal standard with sample dilution within the linear range. With hybrid immunity being now common, it is critical to use protocols adapted to high Ab… read more here.
Keywords: quantification; infection; immunity; binding antibody ... See more keywords
The mechanism of action of the adrenomedullin-binding antibody adrecizumab
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DOI: 10.1186/s13054-018-2074-1
Abstract: With interest we read the review by Levy et al. [1] that provides a thorough overview of current and future therapies aiming to treat vasoplegia, an ubiquitous phenomenon in shock. In their work, the authors… read more here.
Keywords: mechanism action; antibody; antibody adrecizumab; adm ... See more keywords
Immune Response After Rabies Vaccination in Owned Free-Roaming Domestic Dogs in Flores Island, Indonesia
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DOI: 10.3389/fvets.2022.868380
Abstract: Vaccination is the main tool to prevent the circulation of rabies in dog populations. The development of an immune response after vaccination differs between individual dogs and depends on many factors such as dog characteristics,… read more here.
Keywords: binding antibody; dogs flores; immune response; vaccination ... See more keywords
Validation of a Novel Fluorescent Lateral Flow Assay for Rapid Qualitative and Quantitative Assessment of Total Anti-SARS-CoV-2 S-RBD Binding Antibody Units (BAU) from Plasma or Fingerstick Whole-Blood of COVID-19 Vaccinees
Sign Up to like & getrecommendations! Published in 2022 at "Vaccines"
DOI: 10.3390/vaccines10081318
Abstract: Background: Limited commercial LFA assays are available to provide a reliable quantitative measurement of the total binding antibody units (BAU/mL) against the receptor-binding domain of the SARS-CoV-2 spike protein (S-RBD). Aim: To evaluate the performance… read more here.
Keywords: finecaretm; sars cov; antibody units; binding antibody ... See more keywords