Antisense Oligonucleotides Selectively Enter Human-derived Antibiotic-Resistant Bacteria through bacterial-specific ATP-binding Cassette Sugar Transporter.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced materials"
DOI: 10.1002/adma.202300477
Abstract: Current vehicles used to deliver antisense oligonucleotides (ASOs) cannot distinguish between bacterial and mammalian cells, greatly hindering the preclinical or clinical treatment of bacterial infections, especially those caused by antibiotic-resistant bacteria. Herein, we leverage the… read more here.
Keywords: atp binding; antisense oligonucleotides; binding cassette; antibiotic resistant ... See more keywords
The human ATP‐binding cassette (ABC) transporter superfamily
Sign Up to like & getrecommendations! Published in 2022 at "Human Mutation"
DOI: 10.1002/humu.24418
Abstract: The ATP‐binding cassette (ABC) transporter superfamily comprises membrane proteins that efflux various substrates across extra‐ and intracellular membranes. Mutations in ABC genes cause 21 human disorders or phenotypes with Mendelian inheritance, including cystic fibrosis, adrenoleukodystrophy,… read more here.
Keywords: atp binding; binding cassette; abc transporter; abc ... See more keywords
Cloning and tissue distribution of the ATP-binding cassette subfamily G member 2 gene in the marine pufferfish Takifugu rubripes
Sign Up to like & getrecommendations! Published in 2020 at "Fisheries Science"
DOI: 10.1007/s12562-020-01451-z
Abstract: In this study, we cloned the ATP-binding cassette (ABC) subfamily G member 2 gene (Abcg2 gene; breast cancer resistance protein) from the liver of the marine pufferfish Takifugu rubripes, and examined its tissue distribution and… read more here.
Keywords: member gene; subfamily member; atp binding; marine pufferfish ... See more keywords
Maize MS2 encodes an ATP-binding cassette transporter that is essential for anther development
Sign Up to like & getrecommendations! Published in 2021 at "Crop Journal"
DOI: 10.1016/j.cj.2021.04.001
Abstract: Abstract The anther cuticle and pollen exine play a critical role in male gametophyte development. The sporopollenin precursors and cuticular lipid monomers are transported to the surface of the microspores and the epidermis by lipid… read more here.
Keywords: transporter; development; binding cassette; anther development ... See more keywords
Inhibition of microRNA-17-5p reduces the inflammation and lipid accumulation, and up-regulates ATP-binding cassette transporterA1 in atherosclerosis.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2018.11.012
Abstract: Atherosclerosis (AS) is a chronic inflammatory disease of the arterial wall. Macrophages are considered to be closely associated with the development and progression of AS. However, the precise mechanism of miR-17-5p in the macrophages under… read more here.
Keywords: inflammation lipid; lipid accumulation; mir; atp binding ... See more keywords
Transcriptional response of ATP-binding cassette (ABC) transporters to insecticides in the cotton bollworm, Helicoverpa armigera.
Sign Up to like & getrecommendations! Published in 2019 at "Pesticide biochemistry and physiology"
DOI: 10.1016/j.pestbp.2018.12.007
Abstract: When any living organism is frequently exposed to any drugs or toxic substances, they evolve different detoxification mechanism to confront with toxicants during absorption and metabolism. Likewise, the insects have evolved detoxification mechanisms as they… read more here.
Keywords: response atp; helicoverpa armigera; abc transporters; atp binding ... See more keywords
Modulating the function of ATP‐binding cassette subfamily G member 2 (ABCG2) with inhibitor cabozantinib
Sign Up to like & getrecommendations! Published in 2017 at "Pharmacological Research"
DOI: 10.1016/j.phrs.2017.01.024
Abstract: Graphical abstract Figure. No Caption available. ABSTRACT Cabozantinib (XL184) is a small molecule tyrosine kinase receptor inhibitor, which targets c‐Met and VEGFR2. Cabozantinib has been approved by the Food and Drug Administration to treat advanced… read more here.
Keywords: cabozantinib; atp binding; binding cassette; function atp ... See more keywords
Mining of the Novel Virulent ATP-Binding Cassette Importers in Mycobacterium abscessus by Comparative Genomic Strategy.
Sign Up to like & getrecommendations! Published in 2022 at "Microbial drug resistance"
DOI: 10.1089/mdr.2021.0450
Abstract: Background: The virulent ATP-binding cassette (ABC) importers from Mycobacterium abscessus, the most common native multidrug resistant and emerging opportunistic pathogen in rapidly growing NTM, were explored by comparative genomic study, in view of the fact… read more here.
Keywords: virulent atp; tuberculosis; atp binding; binding cassette ... See more keywords
ATP‐binding cassette subfamily A‐1 (ABCA1) levels are increased in the aqueous humour of proliferative diabetic retinopathy patients
Sign Up to like & getrecommendations! Published in 2020 at "Acta Ophthalmologica"
DOI: 10.1111/aos.14550
Abstract: Exp Ophthalmol 248: 1401–1406. Rizzo S, Belting C, Genovesi-Ebert F & di Bartolo E (2010b): Incidence of retinal detachment after small-incision, sutureless pars plana vitrectomy compared with conventional 20-gauge vitrectomy in macular hole and epiretinal… read more here.
Keywords: levels increased; atp binding; subfamily abca1; binding cassette ... See more keywords
Lovastatin attenuates hypertension induced by renal tubule‐specific knockout of ATP‐binding cassette transporter A1, by inhibiting epithelial sodium channels
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14775
Abstract: We have shown that cholesterol is synthesized in the principal cells of renal cortical collecting ducts (CCD) and stimulates the epithelial sodium channels (ENaC). Here we have determined whether lovastatin, a cholesterol synthesis inhibitor, can… read more here.
Keywords: hypertension induced; atp binding; binding cassette; epithelial sodium ... See more keywords
Multiple ATP‐binding cassette transporters are involved in insecticide resistance in the small brown planthopper, Laodelphax striatellus
Sign Up to like & getrecommendations! Published in 2017 at "Insect Molecular Biology"
DOI: 10.1111/imb.12299
Abstract: ATP‐binding cassette (ABC) transporters are membrane‐bound proteins involved in the movement of various substrates, including drugs and insecticides, across the lipid membrane. Demonstration of the role of human ABC transporters in multidrug resistance has led… read more here.
Keywords: abc transporters; atp binding; resistance; binding cassette ... See more keywords