On how the binding cavity of AsqJ dioxygenase controls the desaturation reaction regioselectivity: a QM/MM study
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biological Inorganic Chemistry"
DOI: 10.1007/s00775-018-1575-3
Abstract: The Fe(II)/2-oxoglutarate-dependent dioxygenase AsqJ from Aspergillus nidulans catalyses two pivotal steps in the synthesis of quinolone antibiotic 4′-methoxyviridicatin, i.e., desaturation and epoxidation of a benzodiazepinedione. The previous experimental results signal that, during the desaturation reaction,… read more here.
Keywords: binding cavity; desaturation reaction; reaction; dioxygenase ... See more keywords
Tweezer-type binding cavity formed by the helical folding of a carbazole-pyridine oligomer.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d1cc06569f
Abstract: We have synthesised a new aromatic foldamer based on the carbazole-pyridine oligomers that adopt helical conformations via dipole-dipole interactions and π-stacking between two ethynyl bond-linked monomers. This foldamer scaffold has been further modified into a… read more here.
Keywords: cavity; binding cavity; type binding; tweezer type ... See more keywords
Assessing Als3 Peptide-Binding Cavity and Amyloid-Forming Region Contributions to Candida albicans Invasion of Human Oropharyngeal Epithelial Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.890839
Abstract: Although it is widely recognized that disruption of ALS3 reduces the invasion of Candida albicans germ tubes into mammalian oral epithelial cells, the mechanism of this interaction was unexplored. C. albicans strains with structurally informed… read more here.
Keywords: binding cavity; peptide binding; invasion; epithelial cells ... See more keywords