Direct binding of TFEα opens DNA binding cleft of RNA polymerase
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DOI: 10.1038/s41467-020-19998-x
Abstract: Opening of the DNA binding cleft of cellular RNA polymerase (RNAP) is necessary for transcription initiation but the underlying molecular mechanism is not known. Here, we report on the cryo-electron microscopy structures of the RNAP,… read more here.
Keywords: rna polymerase; binding cleft; dna binding; cleft ... See more keywords
Fine-tuning the extent and dynamics of binding cleft opening as a potential general regulatory mechanism in parvulin-type peptidyl prolyl isomerases
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DOI: 10.1038/srep44504
Abstract: Parvulins or rotamases form a distinct group within peptidyl prolyl cis-trans isomerases. Their exact mode of action as well as the role of conserved residues in the family are still not unambiguously resolved. Using backbone… read more here.
Keywords: binding cleft; parvulin; extent dynamics; peptidyl prolyl ... See more keywords
Mapping DNA conformations and interactions within the binding cleft of bacteriophage T4 single-stranded DNA binding protein (gp32) at single nucleotide resolution
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa1230
Abstract: Abstract In this study, we use single-stranded DNA (oligo-dT) lattices that have been position-specifically labeled with monomer or dimer 2-aminopurine (2-AP) probes to map the local interactions of the DNA bases with the nucleic acid… read more here.
Keywords: protein; single stranded; gp32; binding cleft ... See more keywords