Optimizing hybrid LC-MS/MS binding conditions is critical: impact of biotransformation on quantification of trastuzumab.
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DOI: 10.4155/bio-2018-0196
Abstract: BACKGROUND Hybrid ligand-binding (LB) LC-MS/MS protein quantitative assays involve a LB step for analyte enrichment that has less stringent requirements than the conventional LB assays. RESULTS Herceptin™(trastuzumab) binding to HER2 extracellular domain was evaluated using… read more here.
Keywords: binding conditions; optimizing hybrid; hybrid binding; conditions critical ... See more keywords