Promiscuous Ligands from Experimentally Determined Structures, Binding Conformations, and Protein Family-Dependent Interaction Hotspots
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DOI: 10.1021/acsomega.8b03481
Abstract: Compound promiscuity is often attributed to nonspecific binding or assay artifacts. On the other hand, it is well-known that many pharmaceutically relevant compounds are capable of engaging multiple targets in vivo, giving rise to polypharmacology.… read more here.
Keywords: promiscuous ligands; promiscuous binding; binding conformations; interaction hotspots ... See more keywords