Properly handling negative values in the calculation of binding constants by physicochemical modeling of spectroscopic titration data
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Chemometrics"
DOI: 10.1002/cem.3183
Abstract: To implement equilibrium hard‐modeling of spectroscopic titration data, the analyst must make a variety of crucial data processing choices that address negative absorbance and molar absorptivity values. The efficacy of three such methodological options is… read more here.
Keywords: titration data; negative values; spectroscopic titration; absorbance ... See more keywords
Characterization of complexes between phenethylamine enantiomers and β‐cyclodextrin derivatives by capillary electrophoresis—Determination of binding constants and complex mobilities
Sign Up to like & getrecommendations! Published in 2017 at "ELECTROPHORESIS"
DOI: 10.1002/elps.201600522
Abstract: To optimize chiral separation conditions and to improve the knowledge of enantioseparation, it is important to know the binding constants K between analytes and cyclodextrins and the electrophoretic mobilities of the temporarily formed analyte‐cyclodextrin‐complexes. K… read more here.
Keywords: capillary electrophoresis; cyclodextrin; phenethylamine enantiomers; binding constants ... See more keywords
Encapsulation of phenolic acids into cyclodextrins: A global statistical analysis of the effects of pH, temperature and concentrations on binding constants measured by ACE methods
Sign Up to like & getrecommendations! Published in 2022 at "Electrophoresis"
DOI: 10.1002/elps.202200075
Abstract: Affinity capillary electrophoresis was used for the simultaneous measurement of the pKa values and of the binding constants relative to the encapsulation of naturally occurring phenolic acids (rosmarinic and caffeic acids) with cyclodextrins. A thorough… read more here.
Keywords: acids cyclodextrins; phenolic acids; statistical analysis; temperature ... See more keywords
Boundary values of binding constants determined by affinity capillary electrophoresis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of separation science"
DOI: 10.1002/jssc.202100507
Abstract: This study shows that the upper limit of binding (stability) constants determined by mobility shift affinity capillary electrophoresis can be increased from 104 to 106 -109 L/mol if the lowest possible analyte concentration in samples… read more here.
Keywords: mobility; capillary electrophoresis; binding constants; affinity capillary ... See more keywords
Rapid Estimation of Binding Constants for Cucurbit[8]uril Ternary Complexes Using Electrochemistry
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DOI: 10.1021/acs.analchem.0c04887
Abstract: Supramolecular complexes are of fundamental interests in biomedicines and adaptive materials, and thus facile methods to determine their binding affinity show usefulness in the design of novel drugs and materials. Herein, we report a novel… read more here.
Keywords: ternary complexes; cucurbit uril; using electrochemistry; binding constants ... See more keywords
Binding Constants of Substituted Benzoic Acids with Bovine Serum Albumin
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DOI: 10.3390/ph13020030
Abstract: Experimental data on the affinity of various substances to albumin are essential for the development of empirical models to predict plasma binding of drug candidates. Binding of 24 substituted benzoic acid anions to bovine serum… read more here.
Keywords: constants substituted; binding constants; albumin; substituted benzoic ... See more keywords