Stable pseudo[3]rotaxanes with strong positive binding cooperativity based on shape-persistent aromatic oligoamide macrocycles.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical communications"
DOI: 10.1039/d1cc05193h
Abstract: New aromatic oligoamide macrocycles with C3-symmetry bind a bipyridinium guest (G) to form compact pseudo[3]rotaxanes involving interesting enthalpic and entropic contributions. The observed high stabilities and strong positive binding cooperativity are found in few other… read more here.
Keywords: positive binding; pseudo rotaxanes; strong positive; aromatic oligoamide ... See more keywords
ATP-competitive inhibitors modulate the substrate binding cooperativity of a kinase by altering its conformational entropy
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abo0696
Abstract: ATP-competitive inhibitors are currently the largest class of clinically approved drugs for protein kinases. By targeting the ATP-binding pocket, these compounds block the catalytic activity, preventing substrate phosphorylation. A problem with these drugs, however, is… read more here.
Keywords: binding cooperativity; competitive inhibitors; conformational entropy; substrate binding ... See more keywords