Substrate binding and coupled mechanisms of Vps4p substrate recruitment and release from autoinhibition
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DOI: 10.1038/s41598-025-08418-z
Abstract: The ESCRT pathway’s AAA+ ATPase, Vps4p, remodels ESCRT-III complexes to drive membrane fission. Here, we use peptide binding assays to further the understanding of substrate specificity and the mechanism of autoinhibition. Our results revealed unexpected sequence… read more here.
Keywords: autoinhibition; substrate binding; substrate; binding coupled ... See more keywords