SMARTIV: combined sequence and structure de-novo motif discovery for in-vivo RNA binding data
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky453
Abstract: Abstract Gene expression regulation is highly dependent on binding of RNA-binding proteins (RBPs) to their RNA targets. Growing evidence supports the notion that both RNA primary sequence and its local secondary structure play a role… read more here.
Keywords: rna binding; structure; sequence structure; smartiv ... See more keywords
Rational gRNA design based on transcription factor binding data
Sign Up to like & getrecommendations! Published in 2021 at "Synthetic Biology"
DOI: 10.1093/synbio/ysab014
Abstract: Abstract The clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 system has become a standard tool in many genome engineering endeavors. The endonuclease-deficient version of Cas9 (dCas9) is also a powerful programmable tool for gene regulation.… read more here.
Keywords: rational grna; transcription factor; factor binding; binding data ... See more keywords
Penicillin-Binding Protein Occupancy Dataset for 18 β-Lactams and 4 β-Lactamase Inhibitors in Neisseria gonorrhoeae
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.00692-23
Abstract: The manuscript represents the first N. gonorrhoeae PBP-binding data set for 22 chemically different drugs in two type strains with different genetic background. We have identified three clusters of drugs according to their PBP binding… read more here.
Keywords: binding data; lactamase inhibitors; pbp; pbp binding ... See more keywords