Capturing the free energy of transition state stabilization: insights from the inhibition of mandelate racemase
Sign Up to like & getrecommendations! Published in 2023 at "Philosophical Transactions of the Royal Society B: Biological Sciences"
DOI: 10.1098/rstb.2022.0041
Abstract: Mandelate racemase (MR) catalyses the Mg2+-dependent interconversion of (R)- and (S)-mandelate. To effect catalysis, MR stabilizes the altered substrate in the transition state (TS) by approximately 26 kcal mol–1 (–ΔGtx), such that the upper limit… read more here.
Keywords: transition state; binding determinants; mandelate; mandelate racemase ... See more keywords
Analysis of Binding Determinants for Different Classes of Competitive and Noncompetitive Inhibitors of Glycine Transporters
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23148050
Abstract: Glycine transporters are interesting therapeutic targets as they play significant roles in glycinergic and glutamatergic systems. The search for new selective inhibitors of particular types of glycine transporters (GlyT-1 and GlyT-2) with beneficial kinetics is… read more here.
Keywords: determinants different; glyt glyt; analysis binding; glyt ... See more keywords