FOXO4 interacts with p53 TAD and CRD and inhibits its binding to DNA
Sign Up to like & getrecommendations! Published in 2022 at "Protein Science"
DOI: 10.1002/pro.4287
Abstract: Transcription factor p53 protects cells against tumorigenesis when subjected to various cellular stresses. Under these conditions, p53 interacts with transcription factor Forkhead box O (FOXO) 4, thereby inducing cellular senescence by upregulating the transcription of… read more here.
Keywords: dna; p53 foxo4; binding dna; p53 ... See more keywords
Quantifying Anticancer Drug Doxorubicin Binding to DNA using Optical Tweezers
Sign Up to like & getrecommendations! Published in 2019 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2018.11.2729
Abstract: | 7 Abstract As a chemotherapeutic agent heavily used since 1969, Doxorubicin’s (Doxo) mission is well known and carried out, in a variety of cancers. Doxo halts cancerous cell replication and causes cancerous cells to… read more here.
Keywords: dna; doxo; molecule; binding dna ... See more keywords
Synthetic protein-binding DNA sponge as a tool to tune gene expression and mitigate protein toxicity
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-19552-9
Abstract: Versatile tools for gene expression regulation are vital for engineering gene networks of increasing scales and complexity with bespoke responses. Here, we investigate and repurpose a ubiquitous, indirect gene regulation mechanism from nature, which uses… read more here.
Keywords: gene; binding dna; protein binding; gene expression ... See more keywords
Might Cu(II) binding, DNA cleavage and radical production by YadA fragments be involved in the promotion of F. nucleatum related cancers?
Sign Up to like & getrecommendations! Published in 2022 at "Dalton transactions"
DOI: 10.1039/d2dt00328g
Abstract: In many cases, human microbiota are associated with cancer progression. It was concluded that Fusobacterium nucleatum increases neoplastic changes. This bacterium is naturally present in human dental plaque. However, if it is present in the… read more here.
Keywords: might binding; radical production; production yada; cleavage radical ... See more keywords
Effect of charge redistribution on the binding of DNA nucleotide to carbon nanotube in molecular dynamics
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Simulation"
DOI: 10.1080/08927022.2017.1279285
Abstract: Abstract All-atom molecular dynamics (MD) simulations are performed to study the binding of DNA nucleotides with two carbon nanotubes (CNTs) with similar diameters but different chiralities. Two schemes for assigning partial atomic charges (PACs) are… read more here.
Keywords: carbon; molecular dynamics; dna nucleotide; charge redistribution ... See more keywords
Conformational constraints of cyclopentane peptide nucleic acids facilitate tunable binding to DNA.
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic acids research"
DOI: 10.1093/nar/gkaa1249
Abstract: We report a series of synthetic, nucleic acid mimics with highly customizable thermodynamic binding to DNA. Incorporation of helix-promoting cyclopentanes into peptide nucleic acids (PNAs) increases the melting temperatures (Tm) of PNA+DNA duplexes by approximately… read more here.
Keywords: nucleic acids; dna duplexes; peptide nucleic; dna ... See more keywords