Seroprevalence of Antibodies Specific to Receptor Binding Domain of SARS-CoV-2 and Vaccination Coverage Among Adults in Los Angeles County, April 2021: The LA Pandemic Surveillance Cohort Study
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2021.44258
Abstract: This cross-sectional study estimates the seroprevalence of antibodies specific to the receptor binding domain of the spike protein of SARS-CoV-2 and vaccination coverage among adults in Los Angeles County, California, in April 2021. read more here.
Keywords: antibodies specific; receptor binding; sars cov; binding domain ... See more keywords
Dynamics and electrostatics define an allosteric druggable site within the receptor‐binding domain of SARS‐CoV‐2 spike protein
Sign Up to like & getrecommendations! Published in 2021 at "Febs Letters"
DOI: 10.1002/1873-3468.14038
Abstract: The pathogenesis of the SARS‐CoV‐2 virus initiates through recognition of the angiotensin‐converting enzyme 2 (ACE2) receptor of the host cells by the receptor‐binding domain (RBD) located at the spikes of the virus. Here, using molecular… read more here.
Keywords: binding domain; electrostatics; receptor; sars cov ... See more keywords
Multivalent forms of the ribonuclease H1 hybrid binding domain are high‐affinity binders of RNA–DNA hybrids
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14541
Abstract: The hybrid binding domain (HBD) is a conserved fold present in ribonucleases H1 that selectively recognizes RNA–DNA hybrids, which are structures present in cellular R‐loops and participate in diverse biological processes. We engineered multivalent HBD… read more here.
Keywords: rna dna; hybrid binding; high affinity; affinity ... See more keywords
The positive allosteric modulator BPAM344 and L‐glutamate introduce an active‐like structure of the ligand‐binding domain of GluK2
Sign Up to like & getrecommendations! Published in 2024 at "FEBS Letters"
DOI: 10.1002/1873-3468.14824
Abstract: Kainate receptors belong to the family of ionotropic glutamate receptors and contribute to the majority of fast excitatory neurotransmission. Consequently, they also play a role in brain diseases. Therefore, understanding how these receptors can be… read more here.
Keywords: ligand binding; modulator bpam344; binding domain; positive allosteric ... See more keywords
The Multifunctional Preprotein Binding Domain of SecA
Sign Up to like & getrecommendations! Published in 2024 at "Chembiochem"
DOI: 10.1002/cbic.202400621
Abstract: Sec‐pathway is the main protein secretion pathway in prokaryotes and is essential for their survival. The motor protein SecA is the main coordinator of the pathway in bacteria as it is has evolved to perform… read more here.
Keywords: binding domain; conformational states; preprotein binding; multifunctional preprotein ... See more keywords
A method comparison of three immunoassays for detection of neutralizing antibodies against SARS-CoV-2 receptor-binding domain in individuals with adenovirus type-5-vectored COVID-19 vaccination.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of clinical laboratory analysis"
DOI: 10.1002/jcla.24306
Abstract: OBJECTIVE Detecting neutralizing antibodies targeting receptor-binding domain (RBD) is important for the assessment of humoral protection and vaccine efficacy after vaccination. We compared the performance of three surrogate immunoassays for detection of neutralizing antibodies targeting… read more here.
Keywords: binding domain; comparison; vaccination; detection ... See more keywords
Novel Inhibitors of Androgen Receptor's DNA Binding Domain Identified Using an Ultra-Large Virtual Screening.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular informatics"
DOI: 10.1002/minf.202300026
Abstract: Androgen receptor (AR) inhibition remains the primary strategy to combat the progression of prostate cancer (PC). However, all clinically used AR inhibitors target the ligand-binding domain (LBD), which is highly susceptible to truncations through splicing… read more here.
Keywords: novel inhibitors; virtual screening; androgen receptor; ultra large ... See more keywords
The SH3-binding domain of Cx43 participates in loop/tail interactions critical for Cx43-hemichannel activity
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-017-2722-7
Abstract: Connexin 43 (Cx43) hemichannels establish local signaling networks via the release of ATP and other molecules, but their excessive opening may result in cell death. Hence, the activity of Cx43-hemichannels ought to be critically controlled.… read more here.
Keywords: binding domain; hemichannel activity; sh3 binding; cx43 ... See more keywords
Untangling the Evolution of the Receptor-Binding Motif of SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Molecular Evolution"
DOI: 10.1007/s00239-024-10175-y
Abstract: The spike protein determines the host-range specificity of coronaviruses. In particular, the Receptor-Binding Motif in the spike protein from SARS-CoV-2 contains the amino acids involved in molecular recognition of the host Angiotensin Converting Enzyme 2.… read more here.
Keywords: sars cov; evolution; receptor; binding domain ... See more keywords
Backbone and side-chain assignments for a novel CBM69 starch binding domain AmyP-SBD
Sign Up to like & getrecommendations! Published in 2017 at "Biomolecular NMR Assignments"
DOI: 10.1007/s12104-017-9755-6
Abstract: Starch binding domains (SBDs) are important for the functions of glycoside hydrolysis enzymes such as α-amylases, they have great application potential in biotechnology and industries. AmyP is a newly identified α-amylase belonging to a new… read more here.
Keywords: amyp sbd; binding domain; starch binding;
Backbone and side chain assignments of the second RNA-binding domain of Musashi-1 in its free form and in complex with 5-mer RNA
Sign Up to like & getrecommendations! Published in 2017 at "Biomolecular NMR Assignments"
DOI: 10.1007/s12104-017-9760-9
Abstract: Musashi1 (Msi1) is an RNA-binding protein that is involved in cell fate determination. Here, we report the 1H, 15N, and 13C resonance assignments of Msi1 second RNA-binding domain in free form and in complex with… read more here.
Keywords: binding domain; form complex; free form; rna ... See more keywords