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   Articles with "binding domains" as a keyword



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What monomeric nucleotide binding domains can teach us about dimeric ABC proteins

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recommendations! Published in 2020 at "FEBS Letters"

DOI: 10.1002/1873-3468.13921

Abstract: The classic conceptualization of ATP binding cassette (ABC) transporter function is an ATP‐dependent conformational change coupled to transport of a substrate across a biological membrane via the transmembrane domains (TMDs). The binding of two ATP… read more here.

Keywords: nbd dimerization; nucleotide binding; binding domains; abc proteins ... See more keywords

Structural and biochemical characterization of Clostridium perfringens pili protein B collagen‐binding domains

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recommendations! Published in 2023 at "FEBS Letters"

DOI: 10.1002/1873-3468.14626

Abstract: Sortase‐mediated pili are flexible rod proteins composed of major and minor/tip pilins, playing important roles in the initial adhesion of bacterial cells to host tissues. The pilus shaft is formed by covalent polymerization of major… read more here.

Keywords: collagen; binding domains; tip; clostridium perfringens ... See more keywords

Non‐random distribution of deleterious mutations in the DNA and protein‐binding domains of IRF6 are associated with Van Der Woude syndrome

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recommendations! Published in 2020 at "Molecular Genetics & Genomic Medicine"

DOI: 10.1002/mgg3.1355

Abstract: Abstract Background The development of the face occurs during the early days of intrauterine life by the formation of facial processes from the first Pharyngeal arch. Derangement in these well‐organized fusion events results in Orofacial… read more here.

Keywords: van der; der woude; protein binding; binding domains ... See more keywords
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Backbone resonance assignment of the cAMP-binding domains of the protein kinase A regulatory subunit Iα.

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recommendations! Published in 2021 at "Biomolecular NMR assignments"

DOI: 10.1007/s12104-021-10033-8

Abstract: Protein kinase A (PKA) is the main receptor for the universal cAMP second messenger. PKA is a tetramer with two catalytic (C) and two regulatory (R) subunits, each including two tandem cAMP-binding domains, i.e. CBD-A… read more here.

Keywords: backbone resonance; camp; binding domains; camp binding ... See more keywords

Simulations of Kindlin-2 PIP Binding Domains Reveal Protonation-Dependent Membrane Binding Modes.

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recommendations! Published in 2021 at "Biophysical journal"

DOI: 10.1016/j.bpj.2021.11.021

Abstract: Kindlin-2, a member of the Kindlin family of peripheral membrane proteins, is important for integrin activation and stabilization of epidermal growth factor receptor. It associates with the cytoplasmic face of the plasma membrane via dedicated… read more here.

Keywords: phosphatidylinositol; binding domains; membrane binding; protonation ... See more keywords

Methyllysine binding domains: Structural insight and small molecule probe development.

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recommendations! Published in 2017 at "European journal of medicinal chemistry"

DOI: 10.1016/j.ejmech.2017.04.047

Abstract: A frequent posttranslational modification that regulates gene expression is the mono-, di-, and/or tri- methylation of lysine residues on the histone tails of chromatin. The recognition of methylated lysine marks is facilitated by specific reader… read more here.

Keywords: binding domains; small molecule; methyllysine binding;

Evaluating different DNA binding domains to modulate L1 ORF2p-driven site-specific retrotransposition events in human cells.

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recommendations! Published in 2018 at "Gene"

DOI: 10.1016/j.gene.2017.11.033

Abstract: DNA binding domains (DBDs) have been used with great success to impart targeting capabilities to a variety of proteins creating highly useful genomic tools. We evaluated the ability of five types of DBDs and strategies… read more here.

Keywords: binding domains; retrotransposition; orf2p driven; dna binding ... See more keywords
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Biophysical and structural characterization of novel RAS-binding domains (RBDs) of PI3Kα and PI3Kγ.

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recommendations! Published in 2021 at "Journal of molecular biology"

DOI: 10.1016/j.jmb.2021.166838

Abstract: Phosphatidylinositol-3-kinases (PI3Ks) are lipid kinases that phosphorylate phosphatidylinositol 4,5-bisphosphate to generate a key lipid second messenger, phosphatidylinositol 3,4,5-bisphosphate. PI3Kα and PI3Kγ require activation by RAS proteins to stimulate signaling pathways that control cellular growth, differentiation,… read more here.

Keywords: pi3k; ras binding; binding domains; pi3k pi3k ... See more keywords

Molecular basis of ferredoxin:NADP(+) reductase interactions with FNR binding domains from TROL and Tic62 proteins

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recommendations! Published in 2020 at "Journal of Molecular Structure"

DOI: 10.1016/j.molstruc.2020.128281

Abstract: Abstract The final step of photosynthetic electron transfer from ferredoxin to NADP+ is catalysed by ferredoxin: NADP+ oxidoreductase (FNR). Localization of the FNR on the chloroplastic membrane is attained both, by the dynamic interaction via thylakoid… read more here.

Keywords: fnr binding; binding domains; trol tic62; ferredoxin nadp ... See more keywords

Human Hsp70 Substrate-Binding Domains Recognize Distinct Client Proteins.

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recommendations! Published in 2024 at "Biochemistry"

DOI: 10.1021/acs.biochem.3c00531

Abstract: The 13 Hsp70 proteins in humans act on unique sets of substrates with diversity often being attributed to J-domain-containing protein (Hsp40 or JDP) cofactors. We were therefore surprised to find drastically different binding affinities for… read more here.

Keywords: hsp70 substrate; binding; binding domains; substrate binding ... See more keywords

DNA-PAINT Probe Modifications Support High-Resolution Imaging with Shorter Binding Domains.

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recommendations! Published in 2024 at "ACS nano"

DOI: 10.1021/acsnano.4c06886

Abstract: DNA-based Points Accumulation for Imaging in Nanoscale Topography (DNA-PAINT) is an effective super resolution microscopy technique, and its optimization is key to improve nanoscale detection. The state-of-the-art improvements that are at the base of this… read more here.

Keywords: imager probes; dna paint; binding domains; resolution ... See more keywords