Binding Dynamics of a Stapled Peptide Targeting the Transcription Factor NF−Y
Sign Up to like & getrecommendations! Published in 2024 at "ChemBioChem"
DOI: 10.1002/cbic.202400020
Abstract: Transcription factors (TFs) play a central role in gene regulation, and their malfunction can result in a plethora of severe diseases. TFs are therefore interesting therapeutic targets, but their involvement in protein–protein interaction networks and… read more here.
Keywords: dynamics stapled; transcription factor; binding dynamics; factor ... See more keywords
Following the tracks: how transcription factor binding dynamics control transcription.
Sign Up to like & getrecommendations! Published in 2022 at "Biophysical journal"
DOI: 10.1016/j.bpj.2022.03.026
Abstract: Transcription, the process of copying genetic information from DNA to messenger RNA, is regulated by sequence-specific DNA binding proteins known as transcription factors (TFs). Recent advances in single-molecule tracking (SMT) technologies have enabled visualization of… read more here.
Keywords: dna; dna binding; following tracks; tracks transcription ... See more keywords
Binding memory of liquid molecules
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-025-61630-3
Abstract: Understanding the binding dynamics of liquid molecules is of fundamental importance in physical and life sciences. However, nanoscale fast dynamics pose great challenges for experimental characterization. Conventionally, the binding dynamics have been assumed to be… read more here.
Keywords: memory liquid; memory; liquid molecules; binding dynamics ... See more keywords
Abstract 4035: Elucidating the DNA binding dynamics of EWSR1::FLI1 using biochemical methods
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-4035
Abstract: This work signifies a breakthrough in our ability to study Ewing sarcoma by developing a protocol to purify functional WT EWSR1::FLI1. This development changes the level of detail to which we can study EWSR1::FLI1 and… read more here.
Keywords: fli1; ewsr1 fli1; binding dynamics; dna binding ... See more keywords
Genome‐wide off‐rates reveal how DNA binding dynamics shape transcription factor function
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Systems Biology"
DOI: 10.15252/msb.20209885
Abstract: Protein–DNA interactions are dynamic, and these dynamics are an important aspect of chromatin‐associated processes such as transcription or replication. Due to a lack of methods to study on‐ and off‐rates across entire genomes, protein–DNA interaction… read more here.
Keywords: binding dynamics; transcription; factor; transcription factor ... See more keywords
Distinct Binding Dynamics, Sites and Interactions of Fullerene and Fullerenols with Amyloid-β Peptides Revealed by Molecular Dynamics Simulations
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20082048
Abstract: The pathology Alzheimer’s disease (AD) is associated with the self-assembly of amyloid-β (Aβ) peptides into β-sheet enriched fibrillar aggregates. A promising treatment strategy is focused on the inhibition of amyloid fibrillization of Aβ peptide. Fullerene… read more here.
Keywords: c60 c60; binding dynamics; molecular dynamics; amyloid peptides ... See more keywords