Height, but not binding epitope, affects the potency of synthetic TCR agonists.
Sign Up to like & getrecommendations! Published in 2021 at "Biophysical journal"
DOI: 10.1016/j.bpj.2021.08.027
Abstract: Under physiological conditions, peptide-MHC (pMHC) molecules can trigger T-cell receptors (TCRs) as monovalent ligands that are sparsely distributed on the plasma membrane of an antigen-presenting cell. TCRs can also be triggered by artificial clustering, such… read more here.
Keywords: tcr agonists; synthetic tcr; binding epitope; fab dna ... See more keywords
Minimal Collagen-Binding Epitope of Glycoprotein VI in Human and Mouse Platelets
Sign Up to like & getrecommendations! Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11020423
Abstract: Glycoprotein VI (GPVI) is a platelet-specific receptor for collagen and fibrin, regulating important platelet functions such as platelet adhesion and thrombus growth. Although the blockade of GPVI function is widely recognized as a potent anti-thrombotic… read more here.
Keywords: gpvi; collagen; binding epitope; collagen binding ... See more keywords