Phosphorylation Regulation Mechanism of β2 Integrin for the Binding of Filamin Revealed by Markov State Model
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DOI: 10.1021/acs.jcim.2c01177
Abstract: Leukocyte adhesion deficiency-1 (LAD-1) disorder is a severe immunodeficiency syndrome caused by deficiency or mutation of β2 integrin. The phosphorylation on threonine 758 of β2 integrin acts as a molecular switch inhibiting the binding of… read more here.
Keywords: regulation mechanism; state; regulation; binding filamin ... See more keywords