Evaluation of covalent binding of flutamide and its risk assessment using 19F-NMR
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DOI: 10.1080/00498254.2020.1817626
Abstract: Abstract The formation of reactive metabolites (RMs) is a problem in drug development that sometimes results in severe hepatotoxicity. As detecting RMs themselves is difficult, a covalent binding assay using expensive radiolabelled tracers is usually… read more here.
Keywords: covalent binding; risk assessment; risk; binding flutamide ... See more keywords