Phase I Study of the Anti-HtrA1 Antibody-Binding Fragment FHTR2163 in Geographic Atrophy Secondary to Age-Related Macular Degeneration.
Sign Up to like & getrecommendations! Published in 2021 at "American journal of ophthalmology"
DOI: 10.1016/j.ajo.2021.06.017
Abstract: PURPOSE FHTR2163 is a novel antigen-binding fragment (Fab) directed against high-temperature requirement protein A1 (HtrA1). HtrA1 inhibition may preserve retinal integrity and slow disease progression in geographic atrophy (GA) secondary to age-related macular degeneration (AMD).… read more here.
Keywords: secondary age; age; atrophy secondary; study ... See more keywords
Improving the Developability of an Antigen Binding Fragment by Aspartate Substitutions.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.9b00251
Abstract: Aggregation can be a major challenge in the development of antibody-based pharmaceuticals as it can compromise the quality of the product during bioprocessing, formulation, and drug administration. To avoid aggregation, developability assessment is often run… read more here.
Keywords: developability; aggregation; antigen binding; asp substitutions ... See more keywords
Optimization of TEAD P-Site Binding Fragment Hit into In Vivo Active Lead MSC-4106.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00403
Abstract: The dysregulated Hippo pathway and, consequently, hyperactivity of the transcriptional YAP/TAZ-TEAD complexes is associated with diseases such as cancer. Prevention of YAP/TAZ-TEAD triggered gene transcription is an attractive strategy for therapeutic intervention. The deeply buried… read more here.
Keywords: msc 4106; site; binding fragment; optimization ... See more keywords
The antigen-binding fragment of human gamma immunoglobulin prevents amyloid β-peptide folding into β-sheet to form oligomers
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.17074
Abstract: The amyloid beta-peptide (Aβ) plays a leading role in Alzheimer's disease (AD) physiopathology. Even though monomeric forms of Aβ are harmless to cells, Aβ can aggregate into β-sheet oligomers and fibrils, which are both neurotoxic.… read more here.
Keywords: aggregation; antigen binding; human gamma; sheet ... See more keywords