Disruption of conserved polar interactions causes a sequential release of Bim mutants from the canonical binding groove of Mcl1.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.04.243
Abstract: Mcl1 is an important anti-apoptotic member of the Bcl2 family proteins that are upregulated in several cancer malignancies. The canonical binding groove (CBG) located at the surface of Mcl1 exhibits a critical role in binding… read more here.
Keywords: causes sequential; disruption conserved; mcl1; conserved polar ... See more keywords
Partial peptide dissociation and binding groove plasticity in two major histocompatibility complex class I alleles – differences between alleles versus force field and sampling effects
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DOI: 10.1039/d2ra05324a
Abstract: Major histocompatibility complex class I (MHC I) reports a cell's health status by presenting antigenic peptides inside its binding groove. However, MHC I binding grooves can differ largely in their plasticity, from binding grooves that… read more here.
Keywords: histocompatibility complex; dissociation; major histocompatibility; binding groove ... See more keywords
Phylogenetic analysis of the MCL1 BH3 binding groove and rBH3 sequence motifs in the p53 and INK4 protein families
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DOI: 10.1371/journal.pone.0277726
Abstract: B-cell lymphoma 2 (Bcl-2) proteins are central, conserved regulators of apoptosis. Bcl-2 family function is regulated by binding interactions between the Bcl-2 homology 3 (BH3) motif in pro-apoptotic family members and the BH3 binding groove… read more here.
Keywords: mcl1; bh3; bh3 binding; rbh3 ... See more keywords