High affinity binding of H3K14ac through collaboration of bromodomains 2, 4 and 5 is critical for the molecular and tumor suppressor functions of PBRM1
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DOI: 10.1002/1878-0261.12434
Abstract: Polybromo‐1 (PBRM1) is an important tumor suppressor in kidney cancer. It contains six tandem bromodomains (BDs), which are specialized structures that recognize acetyl‐lysine residues. While BD2 has been found to bind acetylated histone H3 lysine… read more here.
Keywords: tumor suppressor; molecular tumor; binding h3k14ac; tumor ... See more keywords