Steroid receptor/coactivator binding inhibitors: An update
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2019.110471
Abstract: The purpose of this review is to highlight recent developments in small molecules and peptides that block the binding of coactivators to steroid receptors. These coactivator binding inhibitors bind at the coregulator binding groove, also… read more here.
Keywords: receptor coactivator; binding inhibitors; steroid receptors; coactivator binding ... See more keywords
Identification of Slow-Binding Inhibitors of the BoNT/A Protease.
Sign Up to like & getrecommendations! Published in 2022 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.2c00028
Abstract: Botulinum neurotoxin A (BoNT/A) is a lethal toxin, which causes botulism, and is categorized as a bioterrorism threat, which causes flaccid paralysis and death. Botulinum A neurotoxicity is governed through its light chain (LC), a… read more here.
Keywords: binding; identification slow; bont protease; binding inhibitors ... See more keywords
Identification of Non-Zinc Binding Inhibitors of MMP-2 Through Virtual Screening and Subsequent Rescoring.
Sign Up to like & getrecommendations! Published in 2018 at "Drug research"
DOI: 10.1055/a-0586-8308
Abstract: MMP-2 belongs to a large family of proteases called matrix metalloproteinases (MMPs) that degrades type IV collagen, the main structural component of basement membranes and gelatin. The main pathologic role of MMP-2 overexpression is to… read more here.
Keywords: virtual screening; inhibitors mmp; non zinc; mmp ... See more keywords
Binding of Inhibitors to the Monomeric and Dimeric SARS-CoV-2 Mpro
Sign Up to like & getrecommendations! Published in 2020 at "RSC advances"
DOI: 10.26434/chemrxiv.13118378.v1
Abstract: SARS-CoV-2 rapidly infects millions of people worldwide since December 2019. There is still no effective treatment for the virus, resulting in the death of more than one million of patients. Inhibiting the activity of SARS-CoV-2… read more here.
Keywords: cov mpro; dimeric sars; monomeric dimeric; binding inhibitors ... See more keywords