Mutation-induced changes in the receptor-binding interface of the SARS-CoV-2 Delta variant B.1.617.2 and implications for immune evasion
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and Biophysical Research Communications"
DOI: 10.1016/j.bbrc.2021.08.036
Abstract: Following the initial surges of the Alpha (B.1.1.7) and the Beta (B.1.351) variants, a more infectious Delta variant (B.1.617.2) is now surging, further deepening the health crises caused by the pandemic. The sharp rise in… read more here.
Keywords: immune evasion; variant 617; binding interface; delta variant ... See more keywords
Wavelength-Dependent Fluorescent Immunosensors via Incorporation of Polarity Indicators near the Binding Interface of Antibody Fragments.
Sign Up to like & getrecommendations! Published in 2019 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.9b00445
Abstract: Herein, we describe a fluorescent immunosensor designed by incorporating an unnatural amino acid fluorophore into the binding site of an EGFR-specific antibody fragment, resulting in quantifiable EGFR-dependent changes in peak fluorescence emission wavelength. To date,… read more here.
Keywords: polarity; antibody; binding interface; wavelength dependent ... See more keywords