PeSTo-Carbs: Geometric Deep Learning for Prediction of Protein–Carbohydrate Binding Interfaces
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DOI: 10.1021/acs.jctc.3c01145
Abstract: The Protein Structure Transformer (PeSTo), a geometric transformer, has exhibited exceptional performance in predicting protein–protein binding interfaces and distinguishing interfaces with nucleic acids, lipids, small molecules, and ions. In this study, we introduce PeSTo-Carbs, an… read more here.
Keywords: binding interfaces; pesto carbs; protein; carbohydrate binding ... See more keywords
Computationally identifying hot spots in protein-DNA binding interfaces using an ensemble approach
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DOI: 10.1186/s12859-020-03675-3
Abstract: Background Protein-DNA interaction governs a large number of cellular processes, and it can be altered by a small fraction of interface residues, i.e., the so-called hot spots, which account for most of the interface binding… read more here.
Keywords: binding interfaces; protein dna; dna binding; spots protein ... See more keywords
Protein–protein and protein-nucleic acid binding residues important for common and rare sequence variants in human
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DOI: 10.1186/s12859-020-03759-0
Abstract: Background Any two unrelated people differ by about 20,000 missense mutations (also referred to as SAVs: Single Amino acid Variants or missense SNV). Many SAVs have been predicted to strongly affect molecular protein function. Common… read more here.
Keywords: protein; binding interfaces; function; protein protein ... See more keywords