A Method for High‐Throughput Screening of Monoclonal Antibody Internalization Using a DNA/Protein Molecular Staple
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DOI: 10.1002/smtd.202401399
Abstract: The use of monoclonal antibodies (mAbs) as therapeutics or for targeted delivery to specific cells is reliant on understanding mAb‐receptor interactions. Of particular importance is the relationship between mAb binding and internalization into cells. Internalization… read more here.
Keywords: receptor; internalization; method high; binding internalization ... See more keywords
Glycan-independent binding and internalization of human IgM to FCMR, its cognate cellular receptor
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DOI: 10.1038/srep42989
Abstract: IgM is the first antibody to be produced in immune responses and plays an important role in the neutralization of bacteria and viruses. Human IgM is heavily glycosylated, featuring five N-linked glycan sites on the… read more here.
Keywords: human igm; binding internalization; igm; glycan independent ... See more keywords
Abstract B049: Bispecific Aptamers for Enhanced Binding, Internalization, and Therapeutic Delivery in Burkitt Lymphoma
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DOI: 10.1158/1538-7445.pediatric25-b049
Abstract: Burkitt lymphoma is an aggressive cancer that accounts for 30% of all pediatric lymphomas. Due to its aggressive clinical course, patients are immediately started on a high-intensity chemo-immunotherapy protocol with central nervous system (CNS) prophylaxis… read more here.
Keywords: bispecific aptamers; burkitt lymphoma; binding internalization; ramos cells ... See more keywords