TANK-binding kinase 1 (TBK1): an emerging therapeutic target for drug discovery.
Sign Up to like & getrecommendations! Published in 2021 at "Drug discovery today"
DOI: 10.1016/j.drudis.2021.05.016
Abstract: Dysregulation of TANK-binding kinase 1 (TBK1) homeostasis leads to the occurrence and progression of many diseases, such as inflammation, autoimmune diseases, metabolic diseases, and cancer. Therefore, there is a need to develop TBK1 inhibitors as… read more here.
Keywords: drug discovery; tank binding; binding kinase; kinase tbk1 ... See more keywords
Ginsenoside Rc from Panax ginseng exerts anti-inflammatory activity by targeting TANK-binding kinase 1/interferon regulatory factor-3 and p38/ATF-2
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Ginseng Research"
DOI: 10.1016/j.jgr.2016.02.001
Abstract: Background Ginsenoside Rc (G-Rc) is one of the major protopanaxadiol-type saponins isolated from Panax ginseng, a well-known medicinal herb with many beneficial properties including anticancer, anti-inflammatory, antiobesity, and antidiabetic effects. In this study, we investigated… read more here.
Keywords: anti inflammatory; tank binding; kinase; interferon ... See more keywords
Cerebellar Kv3.3 potassium channels activate TANK-binding kinase 1 to regulate trafficking of the cell survival protein Hax-1
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DOI: 10.1038/s41467-021-22003-8
Abstract: Mutations in KCNC3, which encodes the Kv3.3 potassium channel, cause degeneration of the cerebellum, but exactly how the activity of an ion channel is linked to the survival of cerebellar neurons is not understood. Here,… read more here.
Keywords: kv3 potassium; binding kinase; tank binding; kv3 ... See more keywords
Development of novel therapeutics for the treatment of glaucoma based on actin-binding kinase inhibition – in silico approach
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DOI: 10.1039/c9nj05967a
Abstract: Actin-binding kinases are enzymes involved in the regulation of actin polymerization and microtubule disassembly. The inhibition of actin-binding kinases can be used in the treatment of glaucoma, since it relaxes the tissue, increases outflow facility,… read more here.
Keywords: treatment glaucoma; actin binding; binding kinase; inhibition ... See more keywords
Targeting TANK-binding kinase 1 (TBK1) in cancer
Sign Up to like & getrecommendations! Published in 2020 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2020.1826929
Abstract: ABSTRACT Introduction TANK-binding kinase 1 (TBK1) is a Ser/Thr kinase with a central role in coordinating the cellular response to invading pathogens and regulating key inflammatory signaling cascades. While intact TBK1 signaling is required for… read more here.
Keywords: tank binding; kinase tbk1; tbk1 cancer; tbk1 ... See more keywords
Neuropathological characterization of a novel TANK binding kinase (TBK1) gene loss of function mutation associated with amyotrophic lateral sclerosis
Sign Up to like & getrecommendations! Published in 2019 at "Neuropathology and Applied Neurobiology"
DOI: 10.1111/nan.12578
Abstract: Mutations in TANK binding kinase gene (TBK1) are causative in amyotrophic lateral sclerosis (ALS), however correlations between clinical features and TBK1 mutations have not been fully elucidated. We aimed to identify and compare TBK1 mutations… read more here.
Keywords: tank binding; amyotrophic lateral; gene; binding kinase ... See more keywords
PDZ-binding kinase inhibitor OTS514 suppresses the proliferation of oral squamous carcinoma cells.
Sign Up to like & getrecommendations! Published in 2023 at "Oral diseases"
DOI: 10.1111/odi.14533
Abstract: OBJECTIVE PDZ-binding kinase (PBK) has been reported as a poor prognostic factor and is a promising molecular target for anti-cancer therapeutics. Here, we aimed to investigate the effect of specific PBK inhibitor OTS514 on the… read more here.
Keywords: oscc cells; pdz binding; ots514; inhibitor ots514 ... See more keywords
Comparative In Silico Analysis and Functional Characterization of TANK-Binding Kinase 1–Binding Protein 1
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DOI: 10.1177/11779322231164828
Abstract: Protein modelling plays a vital role in the drug discovery process. TANK-binding kinase 1–binding protein 1 is also called an adapter protein, which is encoded by gene TBK1 present in Homo sapiens. It is found… read more here.
Keywords: binding protein; kinase binding; structure; tank binding ... See more keywords
Enhanced Expression of the Key Mitosis Regulator Cyclin B1 Is Mediated by PDZ-Binding Kinase in Islets of Pregnant Mice
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DOI: 10.1210/js.2017-00338
Abstract: Abstract The proliferation of pancreatic β cells is enhanced to enable an increase in β-cell mass and to compensate for insulin resistance during pregnancy. To elucidate the mechanisms involved, we previously investigated islets from pregnant… read more here.
Keywords: binding kinase; kinase; expression; pdz binding ... See more keywords