Synthesis of fluorescent G-quadruplex DNA binding ligands for the comparison of terminal group effects in molecular interaction: Phenol versus methoxybenzene.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.103821
Abstract: A number of new fluorescent nucleic acid binding ligands were synthesized by utilizing the non-specific thiazole orange dye as the basic scaffold for molecular design. Under simple synthetic conditions, the molecular scaffold of thiazole orange… read more here.
Keywords: binding ligands; dna; quadruplex dna; group ... See more keywords
Modulating RNA secondary and tertiary structures by mismatch binding ligands.
Sign Up to like & getrecommendations! Published in 2019 at "Methods"
DOI: 10.1016/j.ymeth.2019.05.006
Abstract: Much recent attention has been focused on small organic molecules binding to non-canonical structures of nucleic acids, especially, RNA. The Human Genome Project and the ENCODE (encyclopedia of DNA elements) project revealed that more than… read more here.
Keywords: binding ligands; molecules binding; dna; base pairs ... See more keywords
Contribution of Electroactive Humic Substances to the Iron‐Binding Ligands Released During Microbial Remineralization of Sinking Particles
Sign Up to like & getrecommendations! Published in 2020 at "Geophysical Research Letters"
DOI: 10.1029/2019gl086685
Abstract: Iron is a key micronutrient in seawater, but concentrations would be negligible without the presence of organic ligands. The processes influencing the ligand pool composition are poorly constrained, limiting our understanding of the controls on… read more here.
Keywords: binding ligands; iron binding; remineralization; remineralization sinking ... See more keywords
Bioaccumulation Pattern of the SARS-CoV-2 Spike Proteins in Pacific Oyster Tissues
Sign Up to like & getrecommendations! Published in 2023 at "Applied and Environmental Microbiology"
DOI: 10.1128/aem.02106-22
Abstract: This is the first article to investigate the SARS-CoV-2 spike protein bioaccumulation pattern and mechanism in Pacific oysters by the histochemical method. Oysters can bioaccumulate SARS-CoV-2 capsid readily by filter-feeding behavior assisted by specific binding… read more here.
Keywords: cov spike; bioaccumulation pattern; bioaccumulation; binding ligands ... See more keywords
Abstract LB430: Identification of therapeutic target in breast cancer using G-quadruplex binding ligands
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-lb430
Abstract: G-quadruplex (G4) motifs are noncanonical nucleic acid structures formed from staked guanine rich tetrads. G4 motifs have been shown to play significant effects on gene expression in all domains of life and are predominantly enriched… read more here.
Keywords: target breast; cancer; binding ligands; breast cancer ... See more keywords