Exploring the binding mechanism of HDAC8 selective inhibitors: Lessons from the modification of Cap group
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29583
Abstract: The abnormal expression of histone deacetylase 8 (HDAC8) has been reported to associate with various cancer entities (colon, breast cancer, pancreas, etc.) as well as parasitic diseases, making HDAC8 gradually develop into an attractive and… read more here.
Keywords: binding mechanism; hdac8; group; modification cap ... See more keywords
Influence of binding mechanism on labeling efficiency and luminous properties of fluorescent cellulose nanocrystals.
Sign Up to like & getrecommendations! Published in 2017 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2017.07.068
Abstract: Cellulose nanocrystals (CNCs) have excellent properties, such as reproducibility, low biodegradability and a large amount of reactive hydroxyl groups on the surface. This study focused on the labeling efficiency and fluorescent properties of the fluorescent… read more here.
Keywords: binding mechanism; labeling efficiency; cncs; properties fluorescent ... See more keywords
Binding mechanism investigations guiding the synthesis of novel condensed 1,4-dihydropyridine derivatives with L-/T-type calcium channel blocking activity.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.05.032
Abstract: Nifedipine and isradipine are prominent examples of calcium channel blockers with a 1,4-dihydropyridine (DHP) scaffold. Although successfully used in clinics since decades for the treatment of hypertension, the binding mechanism to their target, the L-type… read more here.
Keywords: novel; calcium channel; binding mechanism; channel ... See more keywords
Spectroscopic and thermodynamic studies of the binding mechanism of metformin to pepsin
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2018.04.032
Abstract: Abstract Metformin belongs to biguanide class of compound and is an approved drug for the treatment of type II diabetes. Besides, metformin can prevent the occurrence of other diseased conditions like cardiovascular disease, polycystic ovary… read more here.
Keywords: pepsin; binding mechanism; metformin; spectroscopic thermodynamic ... See more keywords
Residue-specific binding mechanisms of Thioflavin T to a surface of flat β-sheets within a peptide self-assembly mimic.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemistry"
DOI: 10.1021/acs.biochem.0c00280
Abstract: Thioflavin T (ThT) is a popular fluorescent dye for detecting amyloid, a protein aggregate with a β-sheet-rich structure that causes many neurodegenerative diseases. Despite the dye's popularity, a detailed understanding of its molecular binding mechanism… read more here.
Keywords: specific binding; binding mechanisms; binding mechanism; tht ... See more keywords
Binding Models of Aβ42 Peptide with Membranes Explored by Molecular Simulations
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.2c00444
Abstract: One of the factors contributing to the toxicity of amyloid-β (Aβ) peptides is the destruction of membrane integrity through Aβ peptide-membrane interactions. The binding of Aβ peptides to membranes has been studied by experiments and… read more here.
Keywords: binding models; bilayer binding; bilayer; peptide bilayer ... See more keywords
Study of SHMT2 Inhibitors and Their Binding Mechanism by Computational Alanine Scanning
Sign Up to like & getrecommendations! Published in 2019 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.9b00370
Abstract: Mitochondrial serine hydroxymethyl transferase isoform 2 (SHMT2) has attracted increasing attention as a pivotal catalyzing regulator of the serine/glycine pathway in the one-carbon metabolism of cancer cells. However, few inhibitors that target this potential anticancer… read more here.
Keywords: binding mechanism; study shmt2; alanine scanning; shmt2 inhibitors ... See more keywords
What Makes a Good Protein–Protein Interaction Stabilizer: Analysis and Application of the Dual-Binding Mechanism
Sign Up to like & getrecommendations! Published in 2023 at "ACS Central Science"
DOI: 10.1021/acscentsci.3c00003
Abstract: Protein–protein interactions (PPIs) are essential for biological processes including immune reactions and diseases. Inhibition of PPIs by drug-like compounds is a common basis for therapeutic approaches. In many cases the flat interface of PP complexes… read more here.
Keywords: binding; protein protein; binding mechanism; mechanism ... See more keywords
Impact of Antigen Density on the Binding Mechanism of IgG Antibodies
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-03942-z
Abstract: The density and distribution pattern of epitopes at the surface of pathogens have a profound impact on immune responses. Although multiple lines of evidence highlight the significance of antigen surface density for antibody binding, a… read more here.
Keywords: impact antigen; binding mechanism; density; recognition ... See more keywords
Binding mechanism of uranyl to transferrin implicated by density functional theory study
Sign Up to like & getrecommendations! Published in 2017 at "RSC Advances"
DOI: 10.1039/c6ra26109d
Abstract: Transferrins have been proposed to be responsible for the in vivo transportation of uranyl. In this work, the binding mechanism of uranyl to transferrin has been studied using density functional theory method. Three possible stepwise… read more here.
Keywords: density functional; binding mechanism; tyr; mechanism uranyl ... See more keywords
Selective cadmium regulation mediated by a cooperative binding mechanism in CadR
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1908610116
Abstract: Significance The highly toxic cadmium ion can cause destructive hazards to living systems by nonspecific and tight binding on functional macromolecules. However, most of the developed cadmium detoxification systems are not sufficient to recognize or… read more here.
Keywords: cooperative binding; binding mechanism; site; cadmium ... See more keywords