Kinetic Methods of Deducing Binding Mechanisms Involving Intrinsically Disordered Proteins.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1197-5_4
Abstract: There are multiple examples of protein-protein interactions involving one intrinsically disordered protein region binding to an ordered protein domain in a coupled binding and folding reaction. Similarly to protein folding studies, much effort has been… read more here.
Keywords: deducing binding; binding mechanisms; mechanisms involving; kinetic methods ... See more keywords
Evaluation of Sequential Extraction Procedure (SEP) to Validate Binding Mechanisms in Soils and Soil-Nano-Calcium Silicate (SNCS) Mixtures
Sign Up to like & getrecommendations! Published in 2020 at "Indian Geotechnical Journal"
DOI: 10.1007/s40098-020-00464-w
Abstract: The soils in hazardous waste sites contain heavy metals which would leach into groundwater by various biotic and abiotic processes and eventually pose a threat to human health by contaminating the drinking water. In order… read more here.
Keywords: extraction; nano calcium; binding mechanisms; sequential extraction ... See more keywords
Residue-specific binding mechanisms of Thioflavin T to a surface of flat β-sheets within a peptide self-assembly mimic.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemistry"
DOI: 10.1021/acs.biochem.0c00280
Abstract: Thioflavin T (ThT) is a popular fluorescent dye for detecting amyloid, a protein aggregate with a β-sheet-rich structure that causes many neurodegenerative diseases. Despite the dye's popularity, a detailed understanding of its molecular binding mechanism… read more here.
Keywords: specific binding; binding mechanisms; binding mechanism; tht ... See more keywords
Metal Cation-Binding Mechanisms of Q-Proline Peptoid Macrocycles in Solution
Sign Up to like & getrecommendations! Published in 2021 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.1c00447
Abstract: The rational design of foldable and functionalizable peptidomimetic scaffolds requires the concerted application of both computational and experimental methods. Recently, a new class of designed peptoid macrocycle incorporating spiroligomer proline mimics (Q-prolines) has been found… read more here.
Keywords: cation; metal cation; binding mechanisms; solution ... See more keywords
Binding Mechanisms of Amyloid-like Peptides to Lipid Bilayers and Effects of Divalent Cations.
Sign Up to like & getrecommendations! Published in 2021 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.1c00140
Abstract: In several neurodegenerative diseases, cell toxicity can emerge from damage produced by amyloid aggregates to lipid membranes. The details accounting for this damage are poorly understood including how individual amyloid peptides interact with phospholipid membranes… read more here.
Keywords: calcium ions; binding mechanisms; lipid bilayers; peptides lipid ... See more keywords
Distinct Binding Mechanisms for Allosteric Sodium Ion in Cannabinoid Receptors.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.1c00760
Abstract: The therapeutic potential of cannabinoid receptors is not fully explored due to psychoactive side effects and lack of selectivity associated with orthosteric ligands. Allosteric modulators have the potential to become selective therapeutics for cannabinoid receptors.… read more here.
Keywords: distinct binding; cannabinoid; mechanisms allosteric; cannabinoid receptors ... See more keywords
Insights into ultra-low affinity lipase-antibody noncovalent complex binding mechanisms
Sign Up to like & getrecommendations! Published in 2022 at "mAbs"
DOI: 10.1080/19420862.2022.2135183
Abstract: ABSTRACT Detection of host cell protein (HCP) impurities is critical to ensuring that recombinant drug products, including monoclonal antibodies (mAbs), are safe. Mechanistic characterization as to how HCPs persist in drug products is important to… read more here.
Keywords: mab; phospholipase; binding mechanisms; lipase ... See more keywords
Binding mechanisms in dendrimer-surfactant complexes.
Sign Up to like & getrecommendations! Published in 2022 at "Physical review. E"
DOI: 10.1103/physreve.105.034501
Abstract: Molecular dynamics simulations were employed to investigate the impact of interactions between dendritic polyeclectrolytes and amphiphilic surfactants on the supramolecular complex formation. We recognize two crucial parameters that govern association of surfactants within dendrimers: surfactant… read more here.
Keywords: mechanisms dendrimer; dendrimer; surfactant complexes; dendrimer surfactant ... See more keywords
Large-Scale Computational Discovery of Binding Motifs in tRNA Fragments
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2021.647449
Abstract: Accumulating evidence has suggested that tRNA-derived fragments (tRFs) could be loaded to Argonaute proteins and function as regulatory small RNAs. However, their mode of action remains largely unknown, and investigations of their binding mechanisms have… read more here.
Keywords: large scale; computational discovery; discovery binding; binding mechanisms ... See more keywords
Binding Mechanisms in Visual Perception and Their Link With Neural Oscillations: A Review of Evidence From tACS
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Psychology"
DOI: 10.3389/fpsyg.2021.643677
Abstract: Neurophysiological studies in humans employing magneto- (MEG) and electro- (EEG) encephalography increasingly suggest that oscillatory rhythmic activity of the brain may be a core mechanism for binding sensory information across space, time, and object features… read more here.
Keywords: binding mechanisms; evidence; tacs; mechanisms visual ... See more keywords
Folding and Binding Mechanisms of the SH2 Domain from Crkl
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12081014
Abstract: SH2 domains are structural modules specialized in the recognition and binding of target sequences containing a phosphorylated tyrosine residue. They are mostly incorporated in the 3D structure of scaffolding proteins that represent fundamental regulators of… read more here.
Keywords: sh2 domain; mechanisms sh2; domain crkl; binding mechanisms ... See more keywords