The unique evolution of the carbohydrate‐binding module CBM20 in laforin
Sign Up to like & getrecommendations! Published in 2018 at "FEBS Letters"
DOI: 10.1002/1873-3468.12994
Abstract: Laforin catalyses glycogen dephosphorylation. Mutations in its gene result in Lafora disease, a fatal progressive myoclonus epilepsy, the hallmark being water‐insoluble, hyperphosphorylated carbohydrate inclusions called Lafora bodies. Human laforin consists of an N‐terminal carbohydrate‐binding module… read more here.
Keywords: cbm20 laforin; carbohydrate binding; binding module; laforin ... See more keywords
Fusion of carbohydrate binding module to mutant alkaline phosphatase for immobilization on cellulose
Sign Up to like & getrecommendations! Published in 2018 at "Biocatalysis and agricultural biotechnology"
DOI: 10.1016/j.bcab.2018.01.003
Abstract: Abstract Immobilized alkaline phosphatase (AP) has the potential to be utilized in biotechnology applications including molecular cloning, inhibitor screening, and the production of phosphorylated compounds. Traditional immobilization methods are limited by specificity and reproducibility, and… read more here.
Keywords: phosphatase; immobilization; carbohydrate binding; mutant alkaline ... See more keywords
Enhancement of catalytic performance of a metagenome-derived thermophilic oligosaccharide-specific xylanase by binding module removal and random mutagenesis.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of bioscience and bioengineering"
DOI: 10.1016/j.jbiosc.2020.09.008
Abstract: Xylo-oligosaccharide (XO) is a promising pre-biotic with applications in food, feed and healthcare products. XO can be produced by enzymatic digestion of xylan with xylanase. In this study, we aimed to improve the biochemical properties… read more here.
Keywords: x11p; xylanase; removal; random mutagenesis ... See more keywords
Biological route to fabricate silica on cellulose using immobilized silicatein fused with a carbohydrate-binding module.
Sign Up to like & getrecommendations! Published in 2020 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.0c00730
Abstract: Silicatein is an enzyme capable of catalyzing silica formation under mild conditions and is a promising catalyst for the fabrication of biohybrid materials. However, unfavorable aggregation of silicatein makes it unsuitable for use in material… read more here.
Keywords: silica cellulose; silica; carbohydrate binding; binding module ... See more keywords
Efficient Immobilization of Bacterial GH Family 46 Chitosanase by Carbohydrate-Binding Module Fusion for the Controllable Preparation of Chitooligosaccharides.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.9b01608
Abstract: Chitooligosaccharide has been reported to possess diverse bioactivities. The development of novel strategies for obtaining optimum degree of polymerization (DP) chitooligosaccharides has become increasingly important. In this study, two glycoside hydrolase family 46 chitosanases were… read more here.
Keywords: immobilization; carbohydrate binding; family; binding module ... See more keywords
Rice apoplastic CBM1-interacting protein counters blast pathogen invasion by binding conserved carbohydrate binding module 1 motif of fungal proteins
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010792
Abstract: When infecting plants, fungal pathogens secrete cell wall-degrading enzymes (CWDEs) that break down cellulose and hemicellulose, the primary components of plant cell walls. Some fungal CWDEs contain a unique domain, named the carbohydrate binding module… read more here.
Keywords: cell; binding module; cbm1; carbohydrate binding ... See more keywords
Activity of a Carbohydrate-Binding Module Therapy, Neumifil, against SARS-CoV-2 Disease in a Hamster Model of Infection
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14050976
Abstract: The rapid global spread of severe acute respiratory coronavirus 2 (SARS-CoV-2) has resulted in an urgent effort to find efficacious therapeutics. Broad-spectrum therapies which could be used for other respiratory pathogens confer advantages, as do… read more here.
Keywords: hamster model; binding module; therapy; carbohydrate binding ... See more keywords
Use of a Preclinical Natural Transmission Model to Study Antiviral Effects of a Carbohydrate-Binding Module Therapy against SARS-CoV-2 in Hamsters
Sign Up to like & getrecommendations! Published in 2023 at "Viruses"
DOI: 10.3390/v15030725
Abstract: The emergence of severe acute respiratory syndrome coronavirus (SARS-CoV-2) and its expansion to a worldwide pandemic resulted in efforts to assess and develop interventions to reduce the disease burden. Despite the introduction of vaccine programmes… read more here.
Keywords: binding module; carbohydrate binding; natural transmission; model ... See more keywords
Roles of Carbohydrate-Binding Module (CBM) of an Endo-β-1,4-Glucanase (Cel5L) from Bacillus sp. KD1014 in Thermostability and Small-Substrate Hydrolyzing Activity.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of microbiology and biotechnology"
DOI: 10.4014/jmb.1810.10001
Abstract: An endo-β-1,4-glucanase gene, cel5L, was cloned using the shot-gun method from Bacillus sp.. The gene, which contained a predicted signal peptide, encoded a protein of 496 amino acid residues, and the molecular mass of the… read more here.
Keywords: cbm; carbohydrate binding; binding module; cel5l ... See more keywords