A Systematic Structure–Activity Study of a New Type of Small Peptidic Transfection Vector Reveals the Importance of a Special Oxo‐Anion‐Binding Motif for Gene Delivery
Sign Up to like & getrecommendations! Published in 2017 at "ChemBioChem"
DOI: 10.1002/cbic.201700433
Abstract: We discovered a new class of artificial peptidic transfection vectors based on an artificial anion‐binding motif, the guanidiniocarbonylpyrrole (GCP) cation. This new type of vector is surprisingly smaller than traditional systems, and our previous work… read more here.
Keywords: new type; peptidic transfection; binding motif; anion binding ... See more keywords
A common binding motif in the ET domain of BRD3 forms polymorphic structural interfaces with host and viral proteins.
Sign Up to like & getrecommendations! Published in 2021 at "Structure"
DOI: 10.1016/j.str.2021.01.010
Abstract: The extraterminal (ET) domain of BRD3 is conserved among BET proteins (BRD2, BRD3, BRD4), interacting with multiple host and viral protein-protein networks. Solution NMR structures of complexes formed between the BRD3 ET domain and either… read more here.
Keywords: host viral; brd3; binding motif; common binding ... See more keywords
Mechanical signals induces reprogramming of mature adipocytes through the YAP/TAZ-binding motif.
Sign Up to like & getrecommendations! Published in 2022 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2022.113109
Abstract: Tissue engineering technology will be the main approach to tissue regeneration in the future and are promising for the treatment of large-area burns and refractory wounds. Dedifferentiated fat cells (DFAT) derived from mature adipocytes (MAs)… read more here.
Keywords: binding motif; taz binding; cell; mature adipocytes ... See more keywords
Targeting the Receptor-Binding Motif of SARS-CoV-2 with D-Peptides Mimicking the ACE2 Binding Helix: Lessons for Inhibiting Omicron and Future Variants of Concern
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Chemical Information and Modeling"
DOI: 10.1021/acs.jcim.2c00500
Abstract: The COVID-19 pandemic continues to spread around the world, with several new variants emerging, particularly those of concern (VOCs). Omicron (B.1.1.529), a recent VOC with many mutations in the spike protein’s receptor-binding domain (RBD), has… read more here.
Keywords: receptor binding; binding motif; targeting receptor; ace2 binding ... See more keywords
RNA-binding motif protein 43 (RBM43) suppresses hepatocellular carcinoma progression through modulation of cyclin B1 expression
Sign Up to like & getrecommendations! Published in 2020 at "Oncogene"
DOI: 10.1038/s41388-020-1380-7
Abstract: RNA-binding proteins play key roles in the posttranscriptional regulation of mRNA during cancer progression. Here, we show that RNA-binding motif protein 43 (RBM43) is significantly downregulated in human tumors, and its low expression is correlated… read more here.
Keywords: binding motif; rna binding; cyclin; expression ... See more keywords
Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Immunology"
DOI: 10.1038/s41423-020-0458-z
Abstract: Coronavirus disease 2019 (COVID-19), caused by the novel human coronavirus SARS-CoV-2, is currently a major threat to public health worldwide. The viral spike protein binds the host receptor angiotensin-converting enzyme 2 (ACE2) via the receptor-binding… read more here.
Keywords: binding motif; neutralizing antibodies; spike protein; sars cov ... See more keywords
Binding motif of ebselen in solution: chalcogen and hydrogen bonds team up
Sign Up to like & getrecommendations! Published in 2020 at "New Journal of Chemistry"
DOI: 10.1039/d0nj04647g
Abstract: Ebselen (2-phenyl-1,2-benzoselenazol-3(2H)one), a glutathione peroxidase mimic, is active against several RNA viruses, among others the retrovirus responsible for the COVID-19 pandemic. In this paper 77Se and 1H NMR studies of ebselen are reported and they… read more here.
Keywords: binding motif; hydrogen; bond; motif ebselen ... See more keywords
F/YGG-motif is an intrinsically disordered nucleic-acid binding motif
Sign Up to like & getrecommendations! Published in 2022 at "RNA Biology"
DOI: 10.1080/15476286.2022.2066336
Abstract: ABSTRACT Heterogeneous nuclear ribonucleoproteins (hnRNP) function in RNA processing, have RNA-recognition motifs (RRMs) and intrinsically disordered, low-complexity domains (LCDs). While RRMs are drivers of RNA binding, there is only limited knowledge about the RNA interaction… read more here.
Keywords: rna binding; binding motif; rna; ygg motif ... See more keywords
Characterization of the binding motif for the T3SS master regulator LcrF in Yersinia pseudotuberculosis.
Sign Up to like & getrecommendations! Published in 2021 at "FEMS microbiology letters"
DOI: 10.1093/femsle/fnab031
Abstract: LcrF is the master regulator that positively regulates the Ysc type III secretion system (T3SS) in Yersinia and shares high similarity to the DNA binding domain of the T3SS master regulator ExsA in Pseudomonas aeruginosa.… read more here.
Keywords: lcrf; master regulator; binding motif; t3ss master ... See more keywords
Glycosylation site Asn168 is important for slow in vivo clearance of recombinant human diamine oxidase heparin-binding motif mutants.
Sign Up to like & getrecommendations! Published in 2022 at "Glycobiology"
DOI: 10.1093/glycob/cwab122
Abstract: Elevated plasma and tissues histamine concentrations can cause severe symptoms in mast cell activation syndrome, mastocytosis or anaphylaxis. Endogenous and recombinant human diamine oxidase (rhDAO) can rapidly and completely degrade histamine, and administration of rhDAO… read more here.
Keywords: clearance; binding motif; motif mutants; diamine oxidase ... See more keywords
Tight junction formation by a claudin mutant lacking the COOH‐terminal PDZ domain‐binding motif
Sign Up to like & getrecommendations! Published in 2022 at "Annals of the New York Academy of Sciences"
DOI: 10.1111/nyas.14881
Abstract: Claudin‐based tight junctions (TJs) are formed at the most apical part of cell–cell contacts in epithelial cells. Previous studies suggest that scaffolding proteins ZO‐1 and ZO‐2 (ZO proteins) determine the location of TJs by interacting… read more here.
Keywords: pdz domain; binding motif; terminal pdz; domain binding ... See more keywords