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   Articles with "binding motifs" as a keyword



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Predicted structural mimicry of spike receptor-binding motifs from highly pathogenic human coronaviruses

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recommendations! Published in 2021 at "Computational and Structural Biotechnology Journal"

DOI: 10.1016/j.csbj.2021.06.041

Abstract: Viruses often encode proteins that mimic host proteins in order to facilitate infection. Little work has been done to understand the potential mimicry of the SARS-CoV-2, SARS-CoV, and MERS-CoV spike proteins, particularly the receptor-binding motifs,… read more here.

Keywords: binding motifs; mimicry; spike; human proteins ... See more keywords

Cholesterol-binding motifs in STING that control endoplasmic reticulum retention mediate anti-tumoral activity of cholesterol-lowering compounds

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recommendations! Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-024-47046-5

Abstract: The cGAS-STING pathway plays a crucial role in anti-tumoral responses by activating inflammation and reprogramming the tumour microenvironment. Upon activation, STING traffics from the endoplasmic reticulum (ER) to Golgi, allowing signalling complex assembly and induction… read more here.

Keywords: cholesterol; binding motifs; endoplasmic reticulum; cholesterol binding ... See more keywords

Dual binding motifs underpin the hierarchical association of perilipins1–3 with lipid droplets

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recommendations! Published in 2019 at "Molecular Biology of the Cell"

DOI: 10.1091/mbc.e18-08-0534

Abstract: Lipid droplets (LDs) in all eukaryotic cells are coated with at least one of the perilipin (Plin) family of proteins. They all regulate key intracellular lipases but do so to significantly different extents. Where more… read more here.

Keywords: hierarchical association; binding motifs; underpin hierarchical; motifs underpin ... See more keywords

Mutational analysis of the flavinylation and binding motifs in two protein targets of the flavin transferase ApbE.

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recommendations! Published in 2019 at "FEMS microbiology letters"

DOI: 10.1093/femsle/fnz252

Abstract: Many flavoproteins belonging to three domain types contain an FMN residue linked through a phosphoester bond to a threonine or serine residue found in a conserved seven-residue motif. The flavinylation reaction is catalyzed by a… read more here.

Keywords: flavinylation; analysis flavinylation; mutational analysis; binding motifs ... See more keywords

Modular discovery of monomeric and dimeric transcription factor binding motifs for large data sets

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recommendations! Published in 2018 at "Nucleic Acids Research"

DOI: 10.1093/nar/gky027

Abstract: Abstract In some dimeric cases of transcription factor (TF) binding, the specificity of dimeric motifs has been observed to differ notably from what would be expected were the two factors to bind to DNA independently… read more here.

Keywords: transcription factor; factor binding; binding motifs; monomeric dimeric ... See more keywords

Many transcription factor families have evolutionarily conserved binding motifs in plants

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recommendations! Published in 2024 at "Plant Physiology"

DOI: 10.1093/plphys/kiaf205

Abstract: Transcription factors control gene expression during development and in response to a broad range of internal and external stimuli. They regulate promoter activity by directly binding cis- regulatory elements in DNA. The angiosperm Arabidopsis thaliana… read more here.

Keywords: transcription factor; binding motifs; factor families; transcription factors ... See more keywords

G3BP/Rin-Binding Motifs Inserted into Flexible Regions of nsP2 Support RNA Replication of Chikungunya Virus

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recommendations! Published in 2022 at "Journal of Virology"

DOI: 10.1128/jvi.01278-22

Abstract: CHIKV is a reemerging alphavirus that has spread throughout more than 60 countries and is the causative agent of chikungunya fever. No approved drugs or vaccines are available for the treatment or prevention of CHIKV… read more here.

Keywords: replication; binding motifs; g3bp rin; rna replication ... See more keywords

RNA-protein binding motifs mining with a new hybrid deep learning based cross-domain knowledge integration approach

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recommendations! Published in 2017 at "BMC Bioinformatics"

DOI: 10.1186/s12859-017-1561-8

Abstract: BackgroundRNAs play key roles in cells through the interactions with proteins known as the RNA-binding proteins (RBP) and their binding motifs enable crucial understanding of the post-transcriptional regulation of RNAs. How the RBPs correctly recognize… read more here.

Keywords: integration; knowledge; binding motifs; binding ... See more keywords

Assessing a computational pipeline to identify binding motifs to the α2β1 integrin

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recommendations! Published in 2023 at "Frontiers in Chemistry"

DOI: 10.3389/fchem.2023.1107400

Abstract: Integrins in the cell surface interact with functional motifs found in the extracellular matrix (ECM) that queue the cell for biological actions such as migration, adhesion, or growth. Multiple fibrous proteins such as collagen or… read more here.

Keywords: computational pipeline; pipeline identify; binding motifs; motifs integrin ... See more keywords
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Large-Scale Computational Discovery of Binding Motifs in tRNA Fragments

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recommendations! Published in 2021 at "Frontiers in Molecular Biosciences"

DOI: 10.3389/fmolb.2021.647449

Abstract: Accumulating evidence has suggested that tRNA-derived fragments (tRFs) could be loaded to Argonaute proteins and function as regulatory small RNAs. However, their mode of action remains largely unknown, and investigations of their binding mechanisms have… read more here.

Keywords: large scale; computational discovery; discovery binding; binding mechanisms ... See more keywords

Two TPL-Binding Motifs of ARF2 Are Involved in Repression of Auxin Responses

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recommendations! Published in 2018 at "Frontiers in Plant Science"

DOI: 10.3389/fpls.2018.00372

Abstract: Auxin signaling is finalized by activator auxin response factors (aARFs) that are released from Auxin/Indole-3-Acetic Acid (Aux/IAA) repressors and directly activate auxin-responsive genes. However, it remains to be answered how repressor ARFs (rARFs) exert their… read more here.

Keywords: tpl; seed; binding motifs; root hair ... See more keywords